Penetrating keratoplasty for herpes simplex keratitis and keratoconus: Allograft rejection and survival

R. J. Epstein, J. A. Seedor, N. G. Dreizen, R. D. Stulting, G. O. Waring, L. A. Wilson, Harrison D Cavanagh

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Abstract

To determine the relationship between corneal allograft rejection and failure, we studied patients who underwent penetrating keratoplasty for herpes simplex keratitis (n = 82) and keratoconus (n = 345), two frequent indications for keratoplasty in young patients, using survival analysis. For first grafts for herpes, the probability of survival was significantly less than it was for keratoconus (P < 0.0001). For second grafts, this difference was less pronounced, and for three or more grafts, the difference in survival was not significant. The incidence of rejection episodes was similar in first grafts for herpes (16.6%) and keratoconus (18.5%) (P > 0.05). However, the incidence of rejection episodes in grafts for herpes was significantly greater than in keratoconus (23.7 versus 17%, P < 0.01). The incidence of failure after rejection episodes (first grafts and regrafts combined) was significantly greater in grafts for herpes (52.4 versus 16.2%, P < 0.001). Because survival after multiple grafts in both groups is poor, additional measures, such as tissue matching, may be necessary to improve the likelihood of success in these high-risk cases.

Original languageEnglish (US)
Pages (from-to)935-944
Number of pages10
JournalOphthalmology
Volume94
Issue number8
StatePublished - 1987

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Herpetic Keratitis
Keratoconus
Penetrating Keratoplasty
Allografts
Transplants
Survival
Corneal Transplantation
Incidence
Survival Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Epstein, R. J., Seedor, J. A., Dreizen, N. G., Stulting, R. D., Waring, G. O., Wilson, L. A., & Cavanagh, H. D. (1987). Penetrating keratoplasty for herpes simplex keratitis and keratoconus: Allograft rejection and survival. Ophthalmology, 94(8), 935-944.

Penetrating keratoplasty for herpes simplex keratitis and keratoconus : Allograft rejection and survival. / Epstein, R. J.; Seedor, J. A.; Dreizen, N. G.; Stulting, R. D.; Waring, G. O.; Wilson, L. A.; Cavanagh, Harrison D.

In: Ophthalmology, Vol. 94, No. 8, 1987, p. 935-944.

Research output: Contribution to journalArticle

Epstein, RJ, Seedor, JA, Dreizen, NG, Stulting, RD, Waring, GO, Wilson, LA & Cavanagh, HD 1987, 'Penetrating keratoplasty for herpes simplex keratitis and keratoconus: Allograft rejection and survival', Ophthalmology, vol. 94, no. 8, pp. 935-944.
Epstein RJ, Seedor JA, Dreizen NG, Stulting RD, Waring GO, Wilson LA et al. Penetrating keratoplasty for herpes simplex keratitis and keratoconus: Allograft rejection and survival. Ophthalmology. 1987;94(8):935-944.
Epstein, R. J. ; Seedor, J. A. ; Dreizen, N. G. ; Stulting, R. D. ; Waring, G. O. ; Wilson, L. A. ; Cavanagh, Harrison D. / Penetrating keratoplasty for herpes simplex keratitis and keratoconus : Allograft rejection and survival. In: Ophthalmology. 1987 ; Vol. 94, No. 8. pp. 935-944.
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