Peptide antigen presentation by non-classical MHC class I molecules

K. Fischer Lindahl

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The mouse major histocompatibility complex contains more than 40 class I genes in addition to those encoding the classical class I molecules. Many of these encode functional class I heavy chains that are expressed and displayed on the cell surface in association with β2-microglobulin. Several laboratories, using genetic, biochemical, and molecular analysis, RMA-S mutant cells, and synthetic peptides, have recently shown that mouse non-classical or class Ib molecules present peptide antigens to T lymphocytes with αβ or γδ receptors. The class Ib genes, with their limited polymorphism, may have evolved to serve specialized presentation functions.

Original languageEnglish (US)
Pages (from-to)117-126
Number of pages10
JournalSeminars in Immunology
Volume5
Issue number2
Publication statusPublished - 1993

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Keywords

  • H-2M3
  • Mta
  • Qa-1
  • Qa-2
  • TL

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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