Peptide toxins directed at the matrix dissolution systems of cancer cells

Arthur E. Frankel, Thomas H. Bugge, Shihui Liu, Daniel A. Vallera, Stephen H. Leppla

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Growth and spread of tumors requires a variety of membrane and extracellular proteases to modify membrane integrins, dissolve the surrounding matrix and release critical growth factors from both the tumor cell surface and surrounding structures. The two major protease systems involved in this process are the matrix metalloproteases and the serine proteases. Genes and gene products for both protease systems are overexpressed in a variety of neoplasms. Thus, these enzymes serve as excellent targets for the delivery of potent cytotoxic molecules to tumors. A number of peptide toxins have been engineered to bind to tumor cells with high levels of surface proteases and their receptors including anthrax toxins, Pseudomonas exotoxin, saporin and diphtheria toxin. These recombinant fusion proteins provide a novel class of anti-cancer agents that will enter clinical trials in the next several years.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalProtein and Peptide Letters
Volume9
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Tumors
Dissolution
Peptide Hydrolases
Cells
Peptides
Neoplasms
Genes
Recombinant Fusion Proteins
Membranes
Diphtheria Toxin
Exotoxins
Metalloproteases
Serine Proteases
Integrins
Intercellular Signaling Peptides and Proteins
Pseudomonas
Molecules
Enzymes
Clinical Trials
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Peptide toxins directed at the matrix dissolution systems of cancer cells. / Frankel, Arthur E.; Bugge, Thomas H.; Liu, Shihui; Vallera, Daniel A.; Leppla, Stephen H.

In: Protein and Peptide Letters, Vol. 9, No. 1, 2002, p. 1-14.

Research output: Contribution to journalArticle

Frankel, Arthur E. ; Bugge, Thomas H. ; Liu, Shihui ; Vallera, Daniel A. ; Leppla, Stephen H. / Peptide toxins directed at the matrix dissolution systems of cancer cells. In: Protein and Peptide Letters. 2002 ; Vol. 9, No. 1. pp. 1-14.
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