Peptides do not induce contractions in gastrointestinal smooth muscle in calcium-free solution

Allen W. Mangel, J. Gregory^Fitz, Ian L. Taylor

Research output: Contribution to journalArticle

2 Scopus citations


1. Smooth muscle from six sites in the cat gastrointestinal tract was evaluated with respect to its ability to generate contractions in calcium-free solutions. 2. Membrane depolarization and carbachol, but not cholecystokinin or neurotensin, increased tension in smooth muscle segments of esophagus, corpus, duodenum, ileum, proximal colon and distal colon in calcium-free solution. 3. Substance-P produced a contractile response in the absence of calcium but only in the corpus and distal colon. 4. These findings indicate that peptide mediated release of intracellular calcium plays a minimal role in activation of cat gastrointestinal smooth muscle.

Original languageEnglish (US)
Pages (from-to)1135-1137
Number of pages3
JournalGeneral Pharmacology
Issue number6
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Pharmacology

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