Percutaneous translumbar spinal cord compression injury in a dog model that uses angioplasty balloons

MR imaging and histopathologic findings

Phillip D. Purdy, Robert T. Duong, Charles L. White, Donna L. Baer, R. Ross Reichard, G. Lee Pride, Christina Adams, Susan Miller, Christa L. Hladik, Zerrin Yetkin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Previous animal models for spinal cord injury required laminectomy and exposure of the spinal cord to create direct trauma, compromising imaging by both surgical artifact and the nature of the production of the injury. Our purpose was to study a model that uses percutaneous intraspinal navigation with an angioplasty balloon, providing a controlled degree of spinal cord compression and allowing improved MR imaging of spinal cord injury. METHODS: Nine mongrel dogs were studied. MR images were obtained of six dogs after technique development in three dogs. Angioplasty balloons measuring 7 or 4 mm in diameter and 2 cm in length were placed in the midthoracic subarachnoid space. Imaging was performed by using a 1.5-T MR imaging unit before and after balloon inflation. The balloon was inflated within 5 seconds and deflated after 30 minutes. T1- and T2-weighted and contrast-enhanced images were acquired. Spinal cords were submitted for pathologic examination. RESULTS: All four animals with 7-mm balloons experienced hemorrhage, and three had axonal injury revealed by histopathologic examination. One of two animals with 4-mm balloons experienced no injury, and one had axonal injury without hemorrhage. Regional parenchymal enhancement was seen in two of the animals with 7-mm balloons. CONCLUSION: This percutaneous spinal cord injury model results in a graduating degree of injury. It differs from previous techniques by avoiding surgical exposure and the associated artifacts, yet it offers histopathologic findings similar to those of human spinal cord injury. The canine spinal cord is amenable to MR imaging with clinical imaging units. Further evaluations with various durations of compression and various balloon sizes are warranted.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume24
Issue number2
StatePublished - Feb 2003

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Spinal Cord Compression
Balloon Angioplasty
Spinal Cord Injuries
Dogs
Wounds and Injuries
Spinal Cord
Artifacts
Hemorrhage
Subarachnoid Space
Laminectomy
Economic Inflation
Canidae
Animal Models

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Percutaneous translumbar spinal cord compression injury in a dog model that uses angioplasty balloons : MR imaging and histopathologic findings. / Purdy, Phillip D.; Duong, Robert T.; White, Charles L.; Baer, Donna L.; Reichard, R. Ross; Pride, G. Lee; Adams, Christina; Miller, Susan; Hladik, Christa L.; Yetkin, Zerrin.

In: American Journal of Neuroradiology, Vol. 24, No. 2, 02.2003, p. 177-184.

Research output: Contribution to journalArticle

Purdy, Phillip D. ; Duong, Robert T. ; White, Charles L. ; Baer, Donna L. ; Reichard, R. Ross ; Pride, G. Lee ; Adams, Christina ; Miller, Susan ; Hladik, Christa L. ; Yetkin, Zerrin. / Percutaneous translumbar spinal cord compression injury in a dog model that uses angioplasty balloons : MR imaging and histopathologic findings. In: American Journal of Neuroradiology. 2003 ; Vol. 24, No. 2. pp. 177-184.
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