Perfluorochemicals as gastrointestinal contrast agents for MR imaging: Preliminary studies in rats and humans

R. F. Mattrey, P. C. Hajek, V. M. Gylys-Morin, L. L. Baker, J. Martin, D. C. Long, D. M. Long

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The ability to distinguish bowel from other intraabdominal structures is essential for the accurate diagnosis of intraabdominal disease with MR. Because perfluorochemicals have no protons, they cause no MR signal. Since they are immiscible with water, they create a signal void in bowel independent of bowel contents and thus are suitable as oral contrast agents. Furthermore, they are tasteless and odorless and have no side effects. We evaluated the use of perfluorochemicals by performing MR scans of the abdomen in rats after the oral administration of unemulsified perfluorohexylbromide or perfluoroctylbromide. Since the latter is approved as an investigational drug for oral use in humans, two volunteers were also studied. Both compounds created signal void in the bowel of both rats and human subjects allowing identification of the gastrointestinal tract. The results suggest that these compounds have potential as oral contrast agents for MR imaging.

Original languageEnglish (US)
Pages (from-to)1259-1263
Number of pages5
JournalAmerican Journal of Roentgenology
Volume148
Issue number6
DOIs
StatePublished - Jan 1 1987

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Gastrointestinal Agents
Contrast Media
Investigational Drugs
Abdomen
Oral Administration
Gastrointestinal Tract
Protons
Volunteers
Water
perfluorohexylbromide
perflubron

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Perfluorochemicals as gastrointestinal contrast agents for MR imaging : Preliminary studies in rats and humans. / Mattrey, R. F.; Hajek, P. C.; Gylys-Morin, V. M.; Baker, L. L.; Martin, J.; Long, D. C.; Long, D. M.

In: American Journal of Roentgenology, Vol. 148, No. 6, 01.01.1987, p. 1259-1263.

Research output: Contribution to journalArticle

Mattrey, R. F. ; Hajek, P. C. ; Gylys-Morin, V. M. ; Baker, L. L. ; Martin, J. ; Long, D. C. ; Long, D. M. / Perfluorochemicals as gastrointestinal contrast agents for MR imaging : Preliminary studies in rats and humans. In: American Journal of Roentgenology. 1987 ; Vol. 148, No. 6. pp. 1259-1263.
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