Perfluorochemicals as US contrast agents for tumor imaging and hepatosplenography: Preliminary clinical results

R. F. Mattrey, G. Strich, R. E. Shelton, B. B. Gosink, G. R. Leopold, T. Lee, J. Forsythe

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

In animals, perfluorochemicals (PFCs) are effective ultrasound (US) contrast agents that produce hepatic, splenic, and tumor enhancement. The use of Fluosol-DA 20%, an emulsion of perfluorodecalin and perfluorotripropylamine, was studied in nine non-critically ill patients with cancer who had liver lesions. US studies without Fluosol were compared with studies obtained 24, 48, and 72 hours after Fluosol infusion. Vital signs and extensive laboratory analyses were performed before and after Fluosol infusion. Liver metastases from colonic, pancreatic, and gastric carcinoma exhibited rim or diffuse enhancement after a Fluosol dose of 1.6 g/kg or greater. Fluosol produced echogenic enhancement of the liver and spleen relative to kidney at a dose of 2.4 g/kg, allowing the detection of nonenhancing lesions. In addition, Fluosol at a dose of 1.6 g/kg or greater allowed detection of lesions not seen before contrast medium was administered in three of the seven patients studied. There was a mild increase in the level of serum glutamic oxaloacetic transaminase in two patients, one given 2.4 and the other 3.2 g/kg of Fluosol. Mild and transient allergic reactions without change in vital signs were experienced by two patients.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalRADIOLOGY
Volume163
Issue number2
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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