Performance of three-dimensional sonoelastography in prostate cancer detection: A comparison between ex vivo and in vivo experiments

B. Castaneda, K. Hoyt, K. Westesson, L. An, J. Yao, L. Baxter, J. Joseph, J. Strang, D. Rubens, K. Parker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

In this paper, we evaluate and compare the performance of three-dimensional (3D) sonoelastography for prostate cancer detection ex vivo and in vivo. Ultrasound (US) B-mode and sonoelastographic volumes were acquired from eleven prostate glands before and after radical prostatectomy. Semi-automatic algorithms were used to segment the surface of the gland from the US B-mode volume and the tumors from sonoelastographic data. To assess the detection performance, 3D sonoelastographic findings were compared in size and position to 3D histological data. One gland was discarded due to poor contact. In the remaining ten, both, in vivo and ex vivo sonoelastography showed similar performance in prostate cancer detection: over 80% accuracy for tumors larger than 4 mm in estimated diameter. These results are an improvement over US B-mode but not yet sufficient to replace biopsy. However, 3D sonoelastography has the potential to become an imaging tool to guide biopsies.

Original languageEnglish (US)
Title of host publication2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages519-522
Number of pages4
ISBN (Print)9781424443895
DOIs
StatePublished - 2009
Event2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
Duration: Sep 20 2009Sep 23 2009

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
Country/TerritoryItaly
CityRome
Period9/20/099/23/09

Keywords

  • Elasticity imaging
  • Prostate cancer detection
  • Sonoelastography
  • Three-dimensional ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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