Perfusion-Guided Monitoring of Tumor Response to Sonoporation and Prediction of Liposomal Doxorubicin Uptake Using Microbubble Contrast Agents

Aditi Bellary, Rajiv Chopra, Shashank Sirsi, Arelly Villarreal, Rojin Eslami, Quincy Undseth, Sonia Hernandez, Bianca Lec, Jessica Kandel, Mark Borden, Sumbul Shaikh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microbubble ultrasound contrast agents (UCAs) are frequently used for in vivo imaging applications to evaluate changes in tumor perfusion using quantitative contrast enhanced ultrasound (qCEUS) imaging. In addition, volumetric oscillation of these microbubbles in an acoustic field can promote drug extravasation into tumor tissue by permeabilizing cell membranes by a technique known as sonoporation. In this study, we propose that qCEUS imaging can be used to effectively monitor the efficacy of sonoporation in vivo. Importantly, we demonstrate that changes in microbubble perfusion kinetics can function as effective predictors of sonoporation efficiency in vivo. However, the overall degree of tumor perfusion - which is not altered by sonoporation - correlates strongly with drug uptake. Our results suggest that qCEUS can be harnessed to provide real-time feedback detailing vascular changes that occur during sonoporation, and that these biologically driven phenomena can be correlated with nanoparticle uptake in tumors. Successful implementation of this strategy could lead to improved methods of monitoring tumor response to therapy in the clinic, thus furthering strides toward the goal of more personalized therapies.

Original languageEnglish (US)
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages1342-1345
Number of pages4
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: Oct 6 2019Oct 9 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period10/6/1910/9/19

Keywords

  • CEUS
  • image guided drug delivery
  • personalized medicine
  • Ultrasound contrast agents (microbubbles)

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Bellary, A., Chopra, R., Sirsi, S., Villarreal, A., Eslami, R., Undseth, Q., Hernandez, S., Lec, B., Kandel, J., Borden, M., & Shaikh, S. (2019). Perfusion-Guided Monitoring of Tumor Response to Sonoporation and Prediction of Liposomal Doxorubicin Uptake Using Microbubble Contrast Agents. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 1342-1345). [8925913] (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2019.8925913