TY - JOUR
T1 - Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation
AU - Parekh, Justin
AU - Roll, Garrett R.
AU - Feng, Sandy
AU - Niemann, Claus U.
AU - Hirose, Ryutaro
PY - 2013/7
Y1 - 2013/7
N2 - Increasing evidence indicates that recipient diabetes is a risk factor for delayed graft function (DGF) after renal transplant and that peri-operative hyperglycemia increases ischemia-reperfusion injury. To evaluate whether peri-operative hyperglycemia as measured in the post-anesthesia care unit (PACU) after transplant is a risk factor for DGF, we retrospectively reviewed 976 adult recipients of deceased donor renal transplants between January 1, 1997 and December 1, 2004. Logistic regression was used to evaluate risk factors for DGF. In our final multivariate model, recipient blood glucose level in the PACU (odds ratio [OR] 1.10 per 25 unit increase, 95% confidence interval (CI) 1.14-2.46, p = 0.03) was a statistically significant predictor of DGF along with donor age (OR 1.02, 95% CI 1.01-1.03, p < 0.01), cold ischemia time (OR 1.04, 95% CI 1.02-1.07, p < 0.01), recipient male gender (OR 1.68, 95% CI 1.14-2.68, p = 0.01), and a panel-reactive antibody >30% (OR 1.92, 95% CI 1.20-3.05, p = 0.01). We conclude that recipient blood glucose measured in the PACU is associated with DGF and begs the question of whether improved peri-operative glucose control will decrease the incidence of DGF.
AB - Increasing evidence indicates that recipient diabetes is a risk factor for delayed graft function (DGF) after renal transplant and that peri-operative hyperglycemia increases ischemia-reperfusion injury. To evaluate whether peri-operative hyperglycemia as measured in the post-anesthesia care unit (PACU) after transplant is a risk factor for DGF, we retrospectively reviewed 976 adult recipients of deceased donor renal transplants between January 1, 1997 and December 1, 2004. Logistic regression was used to evaluate risk factors for DGF. In our final multivariate model, recipient blood glucose level in the PACU (odds ratio [OR] 1.10 per 25 unit increase, 95% confidence interval (CI) 1.14-2.46, p = 0.03) was a statistically significant predictor of DGF along with donor age (OR 1.02, 95% CI 1.01-1.03, p < 0.01), cold ischemia time (OR 1.04, 95% CI 1.02-1.07, p < 0.01), recipient male gender (OR 1.68, 95% CI 1.14-2.68, p = 0.01), and a panel-reactive antibody >30% (OR 1.92, 95% CI 1.20-3.05, p = 0.01). We conclude that recipient blood glucose measured in the PACU is associated with DGF and begs the question of whether improved peri-operative glucose control will decrease the incidence of DGF.
KW - Delayed graft function
KW - Diabetes
KW - Hyperglycemia
KW - Kidney transplant
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U2 - 10.1111/ctr.12174
DO - 10.1111/ctr.12174
M3 - Article
C2 - 23808826
AN - SCOPUS:84881552616
SN - 0902-0063
VL - 27
SP - E424-E430
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 4
ER -