TY - JOUR
T1 - Perinatal Toxicology Screening
T2 - Comparison of Various Maternal and Neonatal Samples
AU - Kim, Ellen
AU - Brion, Luc P.
AU - Meenan, Gerard
AU - Lehrer, Michael
AU - Suresh, Bangalore R.
PY - 1998/3
Y1 - 1998/3
N2 - OBJECTIVES: Because cocaine metabolites are concentrated in amniotic fluid, we designed this study to assess the usefulness of amniotic fluid and that of neonatal gastric aspirate for perinatal drug screening and to compare the concentration of cocaine metabolites in various maternal and neonatal specimens. STUDY DESIGN: We compared the reliability of various maternal and neonatal specimens for detecting drug exposure and the concentration of cocaine metabolites in these specimens. RESULTS: Our data showed that screening for perinatal drug abuse with any single specimen leads to false-negative results. Drug screening with neonatal amniotic fluid, gastric aspirate, or cord blood did not improve the reliability of perinatal drug screening. CONCLUSION: Testing more than one type of body fluid may increase the reliability of perinatal drug screening.
AB - OBJECTIVES: Because cocaine metabolites are concentrated in amniotic fluid, we designed this study to assess the usefulness of amniotic fluid and that of neonatal gastric aspirate for perinatal drug screening and to compare the concentration of cocaine metabolites in various maternal and neonatal specimens. STUDY DESIGN: We compared the reliability of various maternal and neonatal specimens for detecting drug exposure and the concentration of cocaine metabolites in these specimens. RESULTS: Our data showed that screening for perinatal drug abuse with any single specimen leads to false-negative results. Drug screening with neonatal amniotic fluid, gastric aspirate, or cord blood did not improve the reliability of perinatal drug screening. CONCLUSION: Testing more than one type of body fluid may increase the reliability of perinatal drug screening.
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M3 - Article
C2 - 9605301
AN - SCOPUS:0032018754
SN - 0743-8346
VL - 18
SP - 116
EP - 121
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 2
ER -