Perineurial cell hyperplasia in early-onset polyneuropathy with multiple cranial neuropathies

Gil I. Wolfe; Richard D. Brower; Dennis K. Burns

doi:10.1016/S0960-8966(00)00116-4

Perineurial cell hyperplasia in early-onset polyneuropathy with multiple cranial neuropathies

Gil I. Wolfe, Richard D. Brower, Dennis K. Burns

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We describe a patient who as a teenager developed a sensory-motor polyneuropathy with optic atrophy. Over the next three decades, multiple cranial neuropathies appeared. Striking areas of subperineurial cellular proliferation were observed on sural nerve biopsy. The ultrastructural and immunohistochemical characteristics of these aggregates were those of perineurial cell hyperplasia. To our knowledge, this is the second full report associating perineurial cell hyperplasia with a sensory-motor polyneuropathy and the first in the English literature. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	503-506
Number of pages	4
Journal	Neuromuscular Disorders
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/S0960-8966(00)00116-4
State	Published - Oct 2000

Keywords

Cranial neuropathy
Hyperplasia
Optic atrophy
Perineurial cells
Polyneuropathy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Clinical Neurology
Genetics(clinical)

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10.1016/S0960-8966(00)00116-4

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abstract = "We describe a patient who as a teenager developed a sensory-motor polyneuropathy with optic atrophy. Over the next three decades, multiple cranial neuropathies appeared. Striking areas of subperineurial cellular proliferation were observed on sural nerve biopsy. The ultrastructural and immunohistochemical characteristics of these aggregates were those of perineurial cell hyperplasia. To our knowledge, this is the second full report associating perineurial cell hyperplasia with a sensory-motor polyneuropathy and the first in the English literature. Copyright (C) 2000 Elsevier Science B.V.",

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AB - We describe a patient who as a teenager developed a sensory-motor polyneuropathy with optic atrophy. Over the next three decades, multiple cranial neuropathies appeared. Striking areas of subperineurial cellular proliferation were observed on sural nerve biopsy. The ultrastructural and immunohistochemical characteristics of these aggregates were those of perineurial cell hyperplasia. To our knowledge, this is the second full report associating perineurial cell hyperplasia with a sensory-motor polyneuropathy and the first in the English literature. Copyright (C) 2000 Elsevier Science B.V.

KW - Cranial neuropathy

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KW - Perineurial cells

KW - Polyneuropathy

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Perineurial cell hyperplasia in early-onset polyneuropathy with multiple cranial neuropathies

Abstract

Keywords

ASJC Scopus subject areas

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