Periodontitis and myocardial hypertrophy

Jun Ichi Suzuki, Hiroki Sato, Makoto Kaneko, Asuka Yoshida, Norio Aoyama, Shouta Akimoto, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Yuichi Izumi, Mitsuaki Isobe, Issei Komuro

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

There is a deep relationship between cardiovascular disease and periodontitis. It has been reported that myocardial hypertrophy may be affected by periodontitis in clinical settings. Although these clinical observations had some study limitations, they strongly suggest a direct association between severity of periodontitis and left ventricular hypertrophy. However, the detailed mechanisms between myocardial hypertrophy and periodontitis have not yet been elucidated. Recently, we demonstrated that periodontal bacteria infection is closely related to myocardial hypertrophy. In murine transverse aortic constriction models, a periodontal pathogen, Aggregatibacter actinomycetemcomitans markedly enhanced cardiac hypertrophy with matrix metalloproteinase-2 activation, while another pathogen Porphyromonas gingivalis (P.g.) did not accelerate these pathological changes. In the isoproterenol-induced myocardial hypertrophy model, P.g. induced myocardial hypertrophy through Toll-like receptor-2 signaling. From our results and other reports, regulation of chronic inflammation induced by periodontitis may have a key role in the treatment of myocardial hypertrophy. In this article, we review the pathophysiological mechanism between myocardial hypertrophy and periodontitis.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalHypertension Research
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Periodontitis
Hypertrophy
Porphyromonas gingivalis
Aggregatibacter actinomycetemcomitans
Toll-Like Receptor 2
Matrix Metalloproteinase 2
Cardiomegaly
Left Ventricular Hypertrophy
Isoproterenol
Constriction
Cardiovascular Diseases
Inflammation
Bacteria
Infection

Keywords

  • Clinical observation
  • Experimental models
  • Myocardial hypertrophy
  • Periodontitis

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Suzuki, J. I., Sato, H., Kaneko, M., Yoshida, A., Aoyama, N., Akimoto, S., ... Komuro, I. (2017). Periodontitis and myocardial hypertrophy. Hypertension Research, 40(4), 324-328. https://doi.org/10.1038/hr.2016.146

Periodontitis and myocardial hypertrophy. / Suzuki, Jun Ichi; Sato, Hiroki; Kaneko, Makoto; Yoshida, Asuka; Aoyama, Norio; Akimoto, Shouta; Wakayama, Kouji; Kumagai, Hidetoshi; Ikeda, Yuichi; Akazawa, Hiroshi; Izumi, Yuichi; Isobe, Mitsuaki; Komuro, Issei.

In: Hypertension Research, Vol. 40, No. 4, 01.04.2017, p. 324-328.

Research output: Contribution to journalReview article

Suzuki, JI, Sato, H, Kaneko, M, Yoshida, A, Aoyama, N, Akimoto, S, Wakayama, K, Kumagai, H, Ikeda, Y, Akazawa, H, Izumi, Y, Isobe, M & Komuro, I 2017, 'Periodontitis and myocardial hypertrophy', Hypertension Research, vol. 40, no. 4, pp. 324-328. https://doi.org/10.1038/hr.2016.146
Suzuki JI, Sato H, Kaneko M, Yoshida A, Aoyama N, Akimoto S et al. Periodontitis and myocardial hypertrophy. Hypertension Research. 2017 Apr 1;40(4):324-328. https://doi.org/10.1038/hr.2016.146
Suzuki, Jun Ichi ; Sato, Hiroki ; Kaneko, Makoto ; Yoshida, Asuka ; Aoyama, Norio ; Akimoto, Shouta ; Wakayama, Kouji ; Kumagai, Hidetoshi ; Ikeda, Yuichi ; Akazawa, Hiroshi ; Izumi, Yuichi ; Isobe, Mitsuaki ; Komuro, Issei. / Periodontitis and myocardial hypertrophy. In: Hypertension Research. 2017 ; Vol. 40, No. 4. pp. 324-328.
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