Perioperative outcomes following surgical resection of renal cell carcinoma with inferior vena cava thrombus extending above the hepatic veins: A contemporary multicenter experience

E. Jason Abel, R. Houston Thompson, Vitaly Margulis, Jennifer E. Heckman, Megan M. Merril, Oussama M. Darwish, Laura Maria Krabbe, Stephen A. Boorjian, Bradley C. Leibovich, Christopher G. Wood

Research output: Contribution to journalArticle

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Abstract

Background Surgery for renal cell carcinoma (RCC) patients with inferior vena cava (IVC) thrombus above the hepatic veins is technically complex and associated with an increased risk of perioperative morbidity and mortality. However, minimal data exist that describe contemporary perioperative outcomes at major referral centers or the prognostic factors associated with poor outcomes. Objective To determine the preoperative predictors of major complications and 90-d mortality after surgery in RCC patients who have IVC thrombus above the hepatic veins. Design, setting, and participants We reviewed medical records of all RCC patients who had IVC tumor thrombus above hepatic veins and had had surgery between January 2000 and December 2012 at the Mayo Clinic, M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, and the University of Wisconsin Hospital. Outcome measurement and statistical analysis Major complications recorded were defined as ≥3A according to the Clavien-Dindo system within 90 d of surgery. Univariate and multivariate analyses were used to evaluate associations of preoperative variables with risk of major complications or 90-d mortality. Results and limitations A total of 162 patients were identified for study (level 3, 4 in 69, 93 patients, respectively, according to the Neves classification). Cardiopulmonary bypass was used in 60 of 162 patients (37.5%), and 40 patients (24.7%) had preoperative angioembolization. Major complications were reported in 55 patients (34.0%), with the most common being respiratory, cardiac, and hematologic issues. After multivariate analysis, preoperative systemic symptoms and level 4 thrombus were independently associated with increased risk of major complications. Mortality was reported in 17 patients (10.5%) within 90 d after surgery. After multivariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status (PS) and low serum albumin were preoperative factors independently associated with increased risk of 90-d mortality. Conclusions Contemporary perioperative mortality and major complication rates for RCC patients who have upper-level thrombus are 10% and 34%, respectively. Patients who have ECOG PS >1 or low serum albumin have increased risk for perioperative mortality.

Original languageEnglish (US)
Pages (from-to)584-592
Number of pages9
JournalEuropean Urology
Volume66
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Hepatic Veins
Inferior Vena Cava
Renal Cell Carcinoma
Thrombosis
Mortality
Multivariate Analysis
Serum Albumin
Cardiopulmonary Bypass
Medical Records
Neoplasms
Referral and Consultation
Morbidity

Keywords

  • Cardiopulmonary bypass
  • Kidney cancer
  • Outcomes
  • Renal cell carcinoma
  • Thrombus

ASJC Scopus subject areas

  • Urology

Cite this

Perioperative outcomes following surgical resection of renal cell carcinoma with inferior vena cava thrombus extending above the hepatic veins : A contemporary multicenter experience. / Abel, E. Jason; Thompson, R. Houston; Margulis, Vitaly; Heckman, Jennifer E.; Merril, Megan M.; Darwish, Oussama M.; Krabbe, Laura Maria; Boorjian, Stephen A.; Leibovich, Bradley C.; Wood, Christopher G.

In: European Urology, Vol. 66, No. 3, 2014, p. 584-592.

Research output: Contribution to journalArticle

Abel, E. Jason ; Thompson, R. Houston ; Margulis, Vitaly ; Heckman, Jennifer E. ; Merril, Megan M. ; Darwish, Oussama M. ; Krabbe, Laura Maria ; Boorjian, Stephen A. ; Leibovich, Bradley C. ; Wood, Christopher G. / Perioperative outcomes following surgical resection of renal cell carcinoma with inferior vena cava thrombus extending above the hepatic veins : A contemporary multicenter experience. In: European Urology. 2014 ; Vol. 66, No. 3. pp. 584-592.
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title = "Perioperative outcomes following surgical resection of renal cell carcinoma with inferior vena cava thrombus extending above the hepatic veins: A contemporary multicenter experience",
abstract = "Background Surgery for renal cell carcinoma (RCC) patients with inferior vena cava (IVC) thrombus above the hepatic veins is technically complex and associated with an increased risk of perioperative morbidity and mortality. However, minimal data exist that describe contemporary perioperative outcomes at major referral centers or the prognostic factors associated with poor outcomes. Objective To determine the preoperative predictors of major complications and 90-d mortality after surgery in RCC patients who have IVC thrombus above the hepatic veins. Design, setting, and participants We reviewed medical records of all RCC patients who had IVC tumor thrombus above hepatic veins and had had surgery between January 2000 and December 2012 at the Mayo Clinic, M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, and the University of Wisconsin Hospital. Outcome measurement and statistical analysis Major complications recorded were defined as ≥3A according to the Clavien-Dindo system within 90 d of surgery. Univariate and multivariate analyses were used to evaluate associations of preoperative variables with risk of major complications or 90-d mortality. Results and limitations A total of 162 patients were identified for study (level 3, 4 in 69, 93 patients, respectively, according to the Neves classification). Cardiopulmonary bypass was used in 60 of 162 patients (37.5{\%}), and 40 patients (24.7{\%}) had preoperative angioembolization. Major complications were reported in 55 patients (34.0{\%}), with the most common being respiratory, cardiac, and hematologic issues. After multivariate analysis, preoperative systemic symptoms and level 4 thrombus were independently associated with increased risk of major complications. Mortality was reported in 17 patients (10.5{\%}) within 90 d after surgery. After multivariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status (PS) and low serum albumin were preoperative factors independently associated with increased risk of 90-d mortality. Conclusions Contemporary perioperative mortality and major complication rates for RCC patients who have upper-level thrombus are 10{\%} and 34{\%}, respectively. Patients who have ECOG PS >1 or low serum albumin have increased risk for perioperative mortality.",
keywords = "Cardiopulmonary bypass, Kidney cancer, Outcomes, Renal cell carcinoma, Thrombus",
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T1 - Perioperative outcomes following surgical resection of renal cell carcinoma with inferior vena cava thrombus extending above the hepatic veins

T2 - A contemporary multicenter experience

AU - Abel, E. Jason

AU - Thompson, R. Houston

AU - Margulis, Vitaly

AU - Heckman, Jennifer E.

AU - Merril, Megan M.

AU - Darwish, Oussama M.

AU - Krabbe, Laura Maria

AU - Boorjian, Stephen A.

AU - Leibovich, Bradley C.

AU - Wood, Christopher G.

PY - 2014

Y1 - 2014

N2 - Background Surgery for renal cell carcinoma (RCC) patients with inferior vena cava (IVC) thrombus above the hepatic veins is technically complex and associated with an increased risk of perioperative morbidity and mortality. However, minimal data exist that describe contemporary perioperative outcomes at major referral centers or the prognostic factors associated with poor outcomes. Objective To determine the preoperative predictors of major complications and 90-d mortality after surgery in RCC patients who have IVC thrombus above the hepatic veins. Design, setting, and participants We reviewed medical records of all RCC patients who had IVC tumor thrombus above hepatic veins and had had surgery between January 2000 and December 2012 at the Mayo Clinic, M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, and the University of Wisconsin Hospital. Outcome measurement and statistical analysis Major complications recorded were defined as ≥3A according to the Clavien-Dindo system within 90 d of surgery. Univariate and multivariate analyses were used to evaluate associations of preoperative variables with risk of major complications or 90-d mortality. Results and limitations A total of 162 patients were identified for study (level 3, 4 in 69, 93 patients, respectively, according to the Neves classification). Cardiopulmonary bypass was used in 60 of 162 patients (37.5%), and 40 patients (24.7%) had preoperative angioembolization. Major complications were reported in 55 patients (34.0%), with the most common being respiratory, cardiac, and hematologic issues. After multivariate analysis, preoperative systemic symptoms and level 4 thrombus were independently associated with increased risk of major complications. Mortality was reported in 17 patients (10.5%) within 90 d after surgery. After multivariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status (PS) and low serum albumin were preoperative factors independently associated with increased risk of 90-d mortality. Conclusions Contemporary perioperative mortality and major complication rates for RCC patients who have upper-level thrombus are 10% and 34%, respectively. Patients who have ECOG PS >1 or low serum albumin have increased risk for perioperative mortality.

AB - Background Surgery for renal cell carcinoma (RCC) patients with inferior vena cava (IVC) thrombus above the hepatic veins is technically complex and associated with an increased risk of perioperative morbidity and mortality. However, minimal data exist that describe contemporary perioperative outcomes at major referral centers or the prognostic factors associated with poor outcomes. Objective To determine the preoperative predictors of major complications and 90-d mortality after surgery in RCC patients who have IVC thrombus above the hepatic veins. Design, setting, and participants We reviewed medical records of all RCC patients who had IVC tumor thrombus above hepatic veins and had had surgery between January 2000 and December 2012 at the Mayo Clinic, M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, and the University of Wisconsin Hospital. Outcome measurement and statistical analysis Major complications recorded were defined as ≥3A according to the Clavien-Dindo system within 90 d of surgery. Univariate and multivariate analyses were used to evaluate associations of preoperative variables with risk of major complications or 90-d mortality. Results and limitations A total of 162 patients were identified for study (level 3, 4 in 69, 93 patients, respectively, according to the Neves classification). Cardiopulmonary bypass was used in 60 of 162 patients (37.5%), and 40 patients (24.7%) had preoperative angioembolization. Major complications were reported in 55 patients (34.0%), with the most common being respiratory, cardiac, and hematologic issues. After multivariate analysis, preoperative systemic symptoms and level 4 thrombus were independently associated with increased risk of major complications. Mortality was reported in 17 patients (10.5%) within 90 d after surgery. After multivariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status (PS) and low serum albumin were preoperative factors independently associated with increased risk of 90-d mortality. Conclusions Contemporary perioperative mortality and major complication rates for RCC patients who have upper-level thrombus are 10% and 34%, respectively. Patients who have ECOG PS >1 or low serum albumin have increased risk for perioperative mortality.

KW - Cardiopulmonary bypass

KW - Kidney cancer

KW - Outcomes

KW - Renal cell carcinoma

KW - Thrombus

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