Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features

R. I. Linnoila, S. M. Jensen, S. M. Steinberg, J. L. Mulshine, J. C. Eggleston, A. F. Gazdar

Research output: Contribution to journalArticle

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Abstract

Paraffin sections of 247 primary and metastatic non-small cell lung carcinomas, the corresponding non-neoplastic lungs, and 75 other specimens were examined by immunohistochemical procedures using a panel of antibodies against the specific products of peripheral airway cells: the major surfactant-associated protein and 10-kD Clara cell protein. Non-small cell lung carcinoma tumors most frequently positive for either peripheral airway cell marker were adenocarcinomas (41%), especially those with papillolepidic growth pattern (56%), followed by large cell carcinomas (25%), other adenocarcinomas (22%), and squamous cell carcinomas (16%). Immunoreactivity was mainly focal and the expression of the two peripheral airway cell markers was discordant. The incidence of marker expression was similar in metastatic and primary non-small cell lung carcinoma. Other organs and their tumors were negative, with few exceptions. Non-small cell lung carcinomas positive for peripheral airway cell markers were associated with younger age and less-intense smoking, and surfactant-associated protein reactivity was more common in women than in men. Peripheral airway cell markers were independent prognostic factors for survival and delayed development of metastases in patients with less-advanced disease. It is concluded that surfactant-associated protein and 10-kD Clara cell protein are specific markers for non-small cell lung carcinoma and peripheral airway cell differentiation and provide useful tools to study the pathogenesis, biology, and prognosis of non-small cell lung carcinoma.

Original languageEnglish (US)
Pages (from-to)233-243
Number of pages11
JournalAmerican Journal of Clinical Pathology
Volume97
Issue number2
StatePublished - 1992

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Non-Small Cell Lung Carcinoma
Surface-Active Agents
Proteins
Adenocarcinoma
Uteroglobin
Large Cell Carcinoma
Paraffin
Cell Differentiation
Squamous Cell Carcinoma
Neoplasms
Smoking
Neoplasm Metastasis
Lung
Survival
Antibodies
Incidence
Growth

Keywords

  • Adenocarcinoma
  • Clara cell
  • Lung cancer
  • Papillolepidic
  • Smoking
  • Surfactant
  • Type II cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Linnoila, R. I., Jensen, S. M., Steinberg, S. M., Mulshine, J. L., Eggleston, J. C., & Gazdar, A. F. (1992). Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features. American Journal of Clinical Pathology, 97(2), 233-243.

Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features. / Linnoila, R. I.; Jensen, S. M.; Steinberg, S. M.; Mulshine, J. L.; Eggleston, J. C.; Gazdar, A. F.

In: American Journal of Clinical Pathology, Vol. 97, No. 2, 1992, p. 233-243.

Research output: Contribution to journalArticle

Linnoila, RI, Jensen, SM, Steinberg, SM, Mulshine, JL, Eggleston, JC & Gazdar, AF 1992, 'Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features', American Journal of Clinical Pathology, vol. 97, no. 2, pp. 233-243.
Linnoila, R. I. ; Jensen, S. M. ; Steinberg, S. M. ; Mulshine, J. L. ; Eggleston, J. C. ; Gazdar, A. F. / Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features. In: American Journal of Clinical Pathology. 1992 ; Vol. 97, No. 2. pp. 233-243.
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