Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway

So Youn Min, Yuyang Fu, Jack Hutcheson, Tianfu Wu, Elhaum Khobahy, Jiankun Zhu, Kamala Vanarsa, Yong Du, Min Jung Park, Hyun Sil Park, Ramesh Saxena, Ho Youn Kim, Chandra Mohan

Research output: Contribution to journalArticle

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Abstract

Catheters are implanted into the peritoneal cavity during the process of peritoneal dialysis. Though these catheters may be effective and beneficial, the impact of catheters on the immune system is poorly understood. Catheters and other devices implanted in the peritoneal cavity elicit a foreign body reaction. However, the immunological consequences of this remain uncharacterized. To model this, catheters were implanted into the peritoneal cavity of healthy mice. Catheter implantation induced rapid cellular changes within the peritoneal cavity. Whereas B-cells and T-cells were reduced, catheter implantation was associated with the rapid expansion of F4/80-low-positive, CD11b-positive macrophages that elaborated IL-10, and suppressed T-cell division and Th1 skewing in co-culture assays. Peritoneal catheter elicited macrophages had increased Jmjd3 but reduced NF-κB activation, and their emergence was MyD88-dependent. Collectively, these studies indicate that foreign body implantation into the peritoneal cavity is associated with the expansion of suppressor macrophages. Whether peritoneal cavity catheter implantation may have systemic immunoregulatory roles remains to be explored.

Original languageEnglish (US)
Pages (from-to)59-72
Number of pages14
JournalClinical Immunology
Volume143
Issue number1
DOIs
StatePublished - Apr 2012

Fingerprint

Interleukin-10
Catheters
Macrophages
Peritoneal Cavity
Foreign-Body Reaction
T-Lymphocytes
Peritoneal Dialysis
Coculture Techniques
Foreign Bodies
Cell Division
Immune System
B-Lymphocytes
Equipment and Supplies

Keywords

  • Foreign body reaction
  • IL-10
  • Immune regulation
  • Macrophages
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway. / Min, So Youn; Fu, Yuyang; Hutcheson, Jack; Wu, Tianfu; Khobahy, Elhaum; Zhu, Jiankun; Vanarsa, Kamala; Du, Yong; Park, Min Jung; Park, Hyun Sil; Saxena, Ramesh; Kim, Ho Youn; Mohan, Chandra.

In: Clinical Immunology, Vol. 143, No. 1, 04.2012, p. 59-72.

Research output: Contribution to journalArticle

Min, SY, Fu, Y, Hutcheson, J, Wu, T, Khobahy, E, Zhu, J, Vanarsa, K, Du, Y, Park, MJ, Park, HS, Saxena, R, Kim, HY & Mohan, C 2012, 'Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway', Clinical Immunology, vol. 143, no. 1, pp. 59-72. https://doi.org/10.1016/j.clim.2012.01.003
Min, So Youn ; Fu, Yuyang ; Hutcheson, Jack ; Wu, Tianfu ; Khobahy, Elhaum ; Zhu, Jiankun ; Vanarsa, Kamala ; Du, Yong ; Park, Min Jung ; Park, Hyun Sil ; Saxena, Ramesh ; Kim, Ho Youn ; Mohan, Chandra. / Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway. In: Clinical Immunology. 2012 ; Vol. 143, No. 1. pp. 59-72.
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