Permanent alveolar remodeling in canine lung induced by high-altitude residence during maturation

Priya Ravikumar, Dennis J. Bellotto, Robert L. Johnson, Connie C W Hsia

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Young canines born at sea level (SL) and raised for 5 mo at high altitude (HA, 3,800 m), followed by return to SL before somatic maturation, showed enhanced alveolar gas exchange and diffusing capacity at rest and exercise that persisted into adulthood (McDonough P, Dane DM, Hsia CC, Yilmaz C, Johnson RL Jr. J Appl Physiol 100: 474-81, 2006; Hsia CCW, Johnson RL Jr, McDonough P, Dane DM, Hurst MD, Fehmel JL, Wagner HE, Wagner PD. J Appl Physiol 102: 1448-55, 2007). To examine the associated structural response, we quantified lung ultrastructure in male foxhounds raised at 3,800 m HA or their littermates raised at SL (n = 6 each) from 2.5 to 7.5 mo of age. Three years following return to SL, lungs were fixed for morphometric analysis. In HA-exposed animals compared with SL controls, lung volume at a given inflation pressure was higher with enlargement of alveolar ducts and sacs without significant differences in the volumes of alveolar cell components, septal tissue, or in alveolar-capillary surface areas. There was a shift toward a significantly lower harmonic mean thickness of the blood-gas diffusion barrier in HA-raised animals. As a control organ, muscle capillary length density of costal diaphragm was significantly higher in HA-raised animals, indicating parallel adaptation in oxygen transport organs. We conclude that, in actively growing animals, 5 mo of HA exposure that was discontinued before somatic maturation induced acinar remodeling that increased lung compliance and reduced the resistance of blood-gas diffusion barrier to diffusion that persisted into adulthood, but without permanent enhancement of alveolar tissue growth.

Original languageEnglish (US)
Pages (from-to)1911-1917
Number of pages7
JournalJournal of Applied Physiology
Volume107
Issue number6
DOIs
StatePublished - Dec 2009

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Oceans and Seas
Canidae
Lung
Gases
Alveolar Epithelial Cells
Lung Compliance
Economic Inflation
Cellular Structures
Diaphragm
Oxygen
Pressure
Muscles
Growth

Keywords

  • Alveolar duct
  • Alveolar surface area
  • Alveolar tissue volume
  • Blood-gas
  • Diffusion barrier

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Permanent alveolar remodeling in canine lung induced by high-altitude residence during maturation. / Ravikumar, Priya; Bellotto, Dennis J.; Johnson, Robert L.; Hsia, Connie C W.

In: Journal of Applied Physiology, Vol. 107, No. 6, 12.2009, p. 1911-1917.

Research output: Contribution to journalArticle

Ravikumar, Priya ; Bellotto, Dennis J. ; Johnson, Robert L. ; Hsia, Connie C W. / Permanent alveolar remodeling in canine lung induced by high-altitude residence during maturation. In: Journal of Applied Physiology. 2009 ; Vol. 107, No. 6. pp. 1911-1917.
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