Permeability characteristics of muscle membrane

S. E. Schwartz, J. M. Dietschy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Unidirectional flux rates of saturated fatty acids, saturated alcohols, and bile acids were measured in an intact rat diaphragm preparation. The logarithm of the permeability coefficients for fatty acids containing from five to ten carbon atoms was a linear function of the number of carbon atoms in the fatty acid chain. Incremental free energies of solution were +336 cal x mol-1 for the addition of a hydroxyl group and -258 cal x mol-1 for the addition of a methylene group. These incremental free energies were similar to those obtained by other investigators in other animal tissues, and our data suggest a structural similarity between membranes in different tissues and in different species. The muscle membrane exhibited anomalously high permeabilities for fatty acids containing less than five carbon atoms. Since muscle lacks tight junctions, this result suggests that small non-electrolytes traverse polar regions or aqueous pores within the cellular membrane.

Original languageEnglish (US)
Pages (from-to)961-973
Number of pages13
JournalBiochimica et biophysica acta
Volume600
Issue number3
StatePublished - 1980

Fingerprint

Muscle
Permeability
Fatty Acids
Membranes
Muscles
Carbon
Atoms
Free energy
Tissue
Cold Climate
Tight Junctions
Hydraulic conductivity
Diaphragms
Diaphragm
Bile Acids and Salts
Hydroxyl Radical
Rats
Animals
Alcohols
Research Personnel

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schwartz, S. E., & Dietschy, J. M. (1980). Permeability characteristics of muscle membrane. Biochimica et biophysica acta, 600(3), 961-973.

Permeability characteristics of muscle membrane. / Schwartz, S. E.; Dietschy, J. M.

In: Biochimica et biophysica acta, Vol. 600, No. 3, 1980, p. 961-973.

Research output: Contribution to journalArticle

Schwartz, SE & Dietschy, JM 1980, 'Permeability characteristics of muscle membrane', Biochimica et biophysica acta, vol. 600, no. 3, pp. 961-973.
Schwartz, S. E. ; Dietschy, J. M. / Permeability characteristics of muscle membrane. In: Biochimica et biophysica acta. 1980 ; Vol. 600, No. 3. pp. 961-973.
@article{384605ab810b4465a59e4d14908d5809,
title = "Permeability characteristics of muscle membrane",
abstract = "Unidirectional flux rates of saturated fatty acids, saturated alcohols, and bile acids were measured in an intact rat diaphragm preparation. The logarithm of the permeability coefficients for fatty acids containing from five to ten carbon atoms was a linear function of the number of carbon atoms in the fatty acid chain. Incremental free energies of solution were +336 cal x mol-1 for the addition of a hydroxyl group and -258 cal x mol-1 for the addition of a methylene group. These incremental free energies were similar to those obtained by other investigators in other animal tissues, and our data suggest a structural similarity between membranes in different tissues and in different species. The muscle membrane exhibited anomalously high permeabilities for fatty acids containing less than five carbon atoms. Since muscle lacks tight junctions, this result suggests that small non-electrolytes traverse polar regions or aqueous pores within the cellular membrane.",
author = "Schwartz, {S. E.} and Dietschy, {J. M.}",
year = "1980",
language = "English (US)",
volume = "600",
pages = "961--973",
journal = "Biochimica et Biophysica Acta - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Permeability characteristics of muscle membrane

AU - Schwartz, S. E.

AU - Dietschy, J. M.

PY - 1980

Y1 - 1980

N2 - Unidirectional flux rates of saturated fatty acids, saturated alcohols, and bile acids were measured in an intact rat diaphragm preparation. The logarithm of the permeability coefficients for fatty acids containing from five to ten carbon atoms was a linear function of the number of carbon atoms in the fatty acid chain. Incremental free energies of solution were +336 cal x mol-1 for the addition of a hydroxyl group and -258 cal x mol-1 for the addition of a methylene group. These incremental free energies were similar to those obtained by other investigators in other animal tissues, and our data suggest a structural similarity between membranes in different tissues and in different species. The muscle membrane exhibited anomalously high permeabilities for fatty acids containing less than five carbon atoms. Since muscle lacks tight junctions, this result suggests that small non-electrolytes traverse polar regions or aqueous pores within the cellular membrane.

AB - Unidirectional flux rates of saturated fatty acids, saturated alcohols, and bile acids were measured in an intact rat diaphragm preparation. The logarithm of the permeability coefficients for fatty acids containing from five to ten carbon atoms was a linear function of the number of carbon atoms in the fatty acid chain. Incremental free energies of solution were +336 cal x mol-1 for the addition of a hydroxyl group and -258 cal x mol-1 for the addition of a methylene group. These incremental free energies were similar to those obtained by other investigators in other animal tissues, and our data suggest a structural similarity between membranes in different tissues and in different species. The muscle membrane exhibited anomalously high permeabilities for fatty acids containing less than five carbon atoms. Since muscle lacks tight junctions, this result suggests that small non-electrolytes traverse polar regions or aqueous pores within the cellular membrane.

UR - http://www.scopus.com/inward/record.url?scp=0019309431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019309431&partnerID=8YFLogxK

M3 - Article

C2 - 7407154

AN - SCOPUS:0019309431

VL - 600

SP - 961

EP - 973

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

SN - 0304-4165

IS - 3

ER -