Personalised electromechanical model of the heart for the prediction of the acute effects of cardiac resynchronisation therapy

Maxime Sermesant, Florence Billet, Radomir Chabiniok, Tommaso Mansi, Phani Chinchapatnam, Philippe Moireau, Jean Marc Peyrat, Kawal Rhode, Matt Ginks, Pier Lambiase, Simon Arridge, Hervé Delingette, Michel Sorine, C. Aldo Rinaldi, Dominique Chapelle, Reza Razavi, Nicholas Ayache

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac resynchronisation therapy (CRT) has been shown to be an effective adjunctive treatment for patients with dyssynchronous ventricular contraction and symptoms of the heart failure. However, clinical trials have also demonstrated that up to 30% of patients may be classified as non-responders. In this article, we present how the personalisation of an electromechanical model of the myocardium could help the therapy planning for CRT. We describe the four main components of our myocardial model, namely the anatomy, the electrophysiology, the kinematics and the mechanics. For each of these components we combine prior knowledge and observable parameters in order to personalise these models to patient data. Then the acute effects of a pacemaker on the cardiac function are predicted with the in silico model on a clinical case. This is a proof of concept of the potential of virtual physiological models to better select and plan the therapy.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 5th International Conference, FIMH 2009, Proceedings
Pages239-248
Number of pages10
DOIs
StatePublished - 2009
Externally publishedYes
Event5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009 - Nice, France
Duration: Jun 3 2009Jun 5 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5528
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009
Country/TerritoryFrance
CityNice
Period6/3/096/5/09

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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