TY - JOUR
T1 - Personality and Cerebrospinal Fluid Monoamine Metabolites in Alcoholics and Controls
AU - Limson, Rhona
AU - Goldman, David
AU - Roy, Alec
AU - Lamparski, Danuta
AU - Ravitz, Bernard
AU - Adinoff, Bryon
AU - Linnoila, Markku
PY - 1991/5
Y1 - 1991/5
N2 - • Alcoholics as a group have been consistently reported to show differences from controls on various personality-inventories. Moreover, neurobiologic substrates have been postulated to underlie personality dimensions. Therefore, we compared alcoholics with controls on measures of personality and investigated relationships between measures of personality and cerebrospinal fluid monoamine metabolite concentrations. The alcoholics were significantly different from controls on many personality measurements. There were significant, negative correlations between interview-derived lifetime aggression scores and cerebrospinal fluid concentrations of both the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid. However, there were no significant correlations between any cerebrospinal fluid monoamine metabolite concentrations and scores on personality inventories.
AB - • Alcoholics as a group have been consistently reported to show differences from controls on various personality-inventories. Moreover, neurobiologic substrates have been postulated to underlie personality dimensions. Therefore, we compared alcoholics with controls on measures of personality and investigated relationships between measures of personality and cerebrospinal fluid monoamine metabolite concentrations. The alcoholics were significantly different from controls on many personality measurements. There were significant, negative correlations between interview-derived lifetime aggression scores and cerebrospinal fluid concentrations of both the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid. However, there were no significant correlations between any cerebrospinal fluid monoamine metabolite concentrations and scores on personality inventories.
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U2 - 10.1001/archpsyc.1991.01810290049010
DO - 10.1001/archpsyc.1991.01810290049010
M3 - Article
C2 - 1708656
AN - SCOPUS:0025872673
SN - 0003-990X
VL - 48
SP - 437
EP - 441
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 5
ER -