Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls

Rhona Limson, David Goldman, Alec Roy, Danuta Lamparski, Bernard Ravitz, Bryon Adinoff, Markku Linnoila

Research output: Contribution to journalArticle

165 Scopus citations


Alcoholics as a group have been consistently reported to show differences from controls on various personality inventories. Moreover, neurobiologic substrates have been postulated to underlie personality dimensions. Therefore, we compared alcoholics with controls on measures of personality and investigated relationships between measures of personality and cerebrospinal fluid monoamine metabolite concentrations. The alcoholics were significantly different from controls on many personality measurements. There were significant, negative correlations between interview-derived lifetime aggression scores and cerebrospinal fluid concentrations of both the serotonin metabolite 5-hydroxylndoleacetic acid and the dopamine metabolite homovanillic acid. However, there were no significant correlations between any cerebrospinal fluid monoamine metabolite concentrations and scores on personality inventories.

Original languageEnglish (US)
Pages (from-to)437-441
Number of pages5
JournalArchives of General Psychiatry
Issue number5
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Limson, R., Goldman, D., Roy, A., Lamparski, D., Ravitz, B., Adinoff, B., & Linnoila, M. (1991). Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Archives of General Psychiatry, 48(5), 437-441.