Pervasive roles of microRNAs in cardiovascular biology

Eric M. Small, Eric N. Olson

Research output: Contribution to journalReview article

812 Scopus citations

Abstract

First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalNature
Volume469
Issue number7330
DOIs
StatePublished - Jan 20 2011

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