Pet-1 is required across different stages of life to regulate serotonergic function

Chen Liu, Takashi Maejima, Steven C. Wyler, Gemma Casadesus, Stefan Herlitze, Evan S. Deneris

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and behaviors modulated by 5-HT. Several cascade factors are expressed throughout the lifespan, which suggests that their control of behavior might not be temporally restricted to programming normal numbers of 5-HT neurons. We used new mouse conditional targeting approaches to investigate the ongoing requirements for Pet-1 (also called Fev), a cascade factor that is required for the initiation of 5-HT synthesis, but whose expression persists into adulthood. We found that Pet-1 was required after the generation of 5-HT neurons for multiple steps in 5-HT neuron maturation, including axonal innervation of the somatosensory cortex, expression of appropriate firing properties, and the expression of the Htr1a and Htr1b autoreceptors. Pet-1 was still required in adult 5-HT neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.

Original languageEnglish (US)
Pages (from-to)1190-1198
Number of pages9
JournalNature Neuroscience
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2010

Fingerprint

Pets
Serotonin
Neurons
Autoreceptors
Behavior Control
Somatosensory Cortex
Anxiety
Gene Expression

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Liu, C., Maejima, T., Wyler, S. C., Casadesus, G., Herlitze, S., & Deneris, E. S. (2010). Pet-1 is required across different stages of life to regulate serotonergic function. Nature Neuroscience, 13(10), 1190-1198. https://doi.org/10.1038/nn.2623

Pet-1 is required across different stages of life to regulate serotonergic function. / Liu, Chen; Maejima, Takashi; Wyler, Steven C.; Casadesus, Gemma; Herlitze, Stefan; Deneris, Evan S.

In: Nature Neuroscience, Vol. 13, No. 10, 01.10.2010, p. 1190-1198.

Research output: Contribution to journalArticle

Liu, C, Maejima, T, Wyler, SC, Casadesus, G, Herlitze, S & Deneris, ES 2010, 'Pet-1 is required across different stages of life to regulate serotonergic function', Nature Neuroscience, vol. 13, no. 10, pp. 1190-1198. https://doi.org/10.1038/nn.2623
Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES. Pet-1 is required across different stages of life to regulate serotonergic function. Nature Neuroscience. 2010 Oct 1;13(10):1190-1198. https://doi.org/10.1038/nn.2623
Liu, Chen ; Maejima, Takashi ; Wyler, Steven C. ; Casadesus, Gemma ; Herlitze, Stefan ; Deneris, Evan S. / Pet-1 is required across different stages of life to regulate serotonergic function. In: Nature Neuroscience. 2010 ; Vol. 13, No. 10. pp. 1190-1198.
@article{a5f079b42abb4c5da968a72d04f78753,
title = "Pet-1 is required across different stages of life to regulate serotonergic function",
abstract = "Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and behaviors modulated by 5-HT. Several cascade factors are expressed throughout the lifespan, which suggests that their control of behavior might not be temporally restricted to programming normal numbers of 5-HT neurons. We used new mouse conditional targeting approaches to investigate the ongoing requirements for Pet-1 (also called Fev), a cascade factor that is required for the initiation of 5-HT synthesis, but whose expression persists into adulthood. We found that Pet-1 was required after the generation of 5-HT neurons for multiple steps in 5-HT neuron maturation, including axonal innervation of the somatosensory cortex, expression of appropriate firing properties, and the expression of the Htr1a and Htr1b autoreceptors. Pet-1 was still required in adult 5-HT neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.",
author = "Chen Liu and Takashi Maejima and Wyler, {Steven C.} and Gemma Casadesus and Stefan Herlitze and Deneris, {Evan S.}",
year = "2010",
month = "10",
day = "1",
doi = "10.1038/nn.2623",
language = "English (US)",
volume = "13",
pages = "1190--1198",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Pet-1 is required across different stages of life to regulate serotonergic function

AU - Liu, Chen

AU - Maejima, Takashi

AU - Wyler, Steven C.

AU - Casadesus, Gemma

AU - Herlitze, Stefan

AU - Deneris, Evan S.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and behaviors modulated by 5-HT. Several cascade factors are expressed throughout the lifespan, which suggests that their control of behavior might not be temporally restricted to programming normal numbers of 5-HT neurons. We used new mouse conditional targeting approaches to investigate the ongoing requirements for Pet-1 (also called Fev), a cascade factor that is required for the initiation of 5-HT synthesis, but whose expression persists into adulthood. We found that Pet-1 was required after the generation of 5-HT neurons for multiple steps in 5-HT neuron maturation, including axonal innervation of the somatosensory cortex, expression of appropriate firing properties, and the expression of the Htr1a and Htr1b autoreceptors. Pet-1 was still required in adult 5-HT neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.

AB - Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and behaviors modulated by 5-HT. Several cascade factors are expressed throughout the lifespan, which suggests that their control of behavior might not be temporally restricted to programming normal numbers of 5-HT neurons. We used new mouse conditional targeting approaches to investigate the ongoing requirements for Pet-1 (also called Fev), a cascade factor that is required for the initiation of 5-HT synthesis, but whose expression persists into adulthood. We found that Pet-1 was required after the generation of 5-HT neurons for multiple steps in 5-HT neuron maturation, including axonal innervation of the somatosensory cortex, expression of appropriate firing properties, and the expression of the Htr1a and Htr1b autoreceptors. Pet-1 was still required in adult 5-HT neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.

UR - http://www.scopus.com/inward/record.url?scp=77957285177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957285177&partnerID=8YFLogxK

U2 - 10.1038/nn.2623

DO - 10.1038/nn.2623

M3 - Article

C2 - 20818386

AN - SCOPUS:77957285177

VL - 13

SP - 1190

EP - 1198

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 10

ER -