PET and NMR dual acquisition (PANDA): Applications to isolated, perfused rat hearts

Pamela B. Garlick, Paul K. Marsden, Alison C. Cave, Harold G. Parkes, Randal Slates, Yiping Shao, Robert W. Silverman, Simon R. Cherry

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Positron emission tomography and nuclear magnetic resonance spectroscopy are non-invasive techniques that allow serial metabolic measurements to he obtained in a single subject. Significant advantages could be obtained if both types of scans could be acquired with a single machine. A small-scale PET scanner, designed to operate in a high magnetic field, was therefore constructed and inserted into the top half of a 7.3 cm bore, 9.4 T NMR magnet and its performance characterized. The magnetic field did not significantly affect either the sensitivity (~3 kcps/MBq) or the spatial resolution (2.0 mm full width at half maximum, measured using a 0.25 mm diameter line source) of the scanner. However, the presence of the PET scanner resulted in a small decrease in field homogeneity. The first, simultaneous 31P NMR spectra (200, 80°pulses collected at 6 s intervals) and PET images (transverse, mid- ventricular slices at the level of the mitral value) from isolated, perfused rat hearts were acquired using a specially designed NMR probe inserted into the bottom half of the magnet. The PET images were of excellent quality, enabling the left ventricular wall and interventricular septum to be clearly seen. In conclusion, we have demonstrated the simultaneous acquisition of PET and NMR data from perfused rat hearts; we believe that the combination of these two powerful techniques has tremendous potential in both the laboratory and the clinic.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalNMR in biomedicine
Volume10
Issue number3
DOIs
StatePublished - May 1997

Keywords

  • NMR spectroscopy
  • PET
  • Perfused hearts

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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    Garlick, P. B., Marsden, P. K., Cave, A. C., Parkes, H. G., Slates, R., Shao, Y., Silverman, R. W., & Cherry, S. R. (1997). PET and NMR dual acquisition (PANDA): Applications to isolated, perfused rat hearts. NMR in biomedicine, 10(3), 138-142. https://doi.org/10.1002/(SICI)1099-1492(199705)10:3<138::AID-NBM474>3.0.CO;2-H