PET and SPECT dual-tracer imaging: Correction of 511keV photon's down-scatter effect on SPECT

Tianyu Ma, Yiping Shao, Rutao Yao, Phani Manchiraju

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

This work was part of the feasibility study of performing simultaneous PET and SPECT imaging with a microPET scanner. SPECT data were acquired with slit-slat collimation by inserting a slit-slat collimator into microPET's detector ring but were contaminated by 511 keV photons' down-scattered events from PET tracer. In this study, contribution of down-scattered events in Tc-99m energy window (135-145 keV) was characterized through Monte Carlo simulation and measurements. With relative ratio of Tc-99m and F-18 activity being 1:1, ratio of recorded events from Tc-99m and F-18 source was 1:18.31. Nevertheless, simulation results revealed that the majority of down-scattering effects occurred in the detector crystals and thus were less object dependent. We investigated two subtraction-based compensation methods. The first method used an auxiliary energy window (AEW) and the second method employed extra shielding measurement (ESM) to acquire down-scatter- only data. Simulated and experimental studies showed improved image quality after applying the correction methods. With the activity ratio of SPECT tracer to PET tracer being 5:1, good SPECT images were obtained after correction, which were comparable to those from pure SPECT imaging.

Original languageEnglish (US)
Title of host publication2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Pages3404-3407
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States
Duration: Oct 27 2007Nov 3 2007

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

Other2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
CountryUnited States
CityHonolulu, HI
Period10/27/0711/3/07

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Ma, T., Shao, Y., Yao, R., & Manchiraju, P. (2007). PET and SPECT dual-tracer imaging: Correction of 511keV photon's down-scatter effect on SPECT. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC (pp. 3404-3407). [4436861] (IEEE Nuclear Science Symposium Conference Record; Vol. 5). https://doi.org/10.1109/NSSMIC.2007.4436861