PET-based primary tumor volumetric parameters and survival of patients with non-small cell lung carcinoma

Jessica Davison, Gustavo Mercier, Gregory Russo, Rathan M. Subramaniam

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

OBJECTIVE. The purpose of the study was to assess metabolic tumor volume and total glycolytic activity of the primary tumor as prognostic parameters for outcome in patients with non-small cell lung carcinoma (NSCLC). MATERIALS AND METHODS. Thirty-nine patients who had undergone a baseline staging PET/CT examination at our institution for the diagnosis of NSCLC were retrospectively identified. The maximum standardized uptake value (SUVmax), metabolic tumor volume, and total glycolytic activity were segmented from PET using the gradient method; 12-month survival and overall survival at the end of follow-up were used as outcome measures. Multivariate logistic regression, receiver operating characteristic curve analysis, and Kaplan-Meier curves for survival analysis were generated and compared using the Mantel-Cox log-rank test. RESULTS. The mean gradient-based metabolic tumor volume and gradient-based total glycolytic activity were significantly greater in the patients who died (93.3 mL and 597.5 g) than in those who survived (19.3 mL and 193.9 g, respectively) (p < 0.003 and p < 0.031). There was no statistically significant difference in the mean SUVmax between the patients who survived (12.7) at 12 months and those who had died (13.1) (p = 0.85). On multivariate analysis, gradientbased metabolic tumor volume was the only variable associated with 12-month mortality when adjusted for all other factors.. The area under the curve (AUC) for gradient-based metabolic tumor volume was 0.77 (p < 0.006). A significant difference in the time to survival was observed between high and low gradient-based metabolic tumor volume (log-rank p < 0.05) cohorts using the median gradient-based metabolic tumor volume (9.7 mL) as the cut point. CONCLUSION. PET-based volumetric imaging parameters are potential prognostic markers of outcome in patients with NSCLC.

Original languageEnglish (US)
Pages (from-to)635-640
Number of pages6
JournalAmerican Journal of Roentgenology
Volume200
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • Metabolic tumor volume
  • Non-small cell lung carcinoma
  • PET
  • Total glycolytic activity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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