PEt of human prostate cancer xenografts in mice with increased uptake of64CuCl2

Fangyu Peng, Xin Lu, James Janisse, Otto Muzik, Anthony F. Shields

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. Results: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gramof tissue: 3.6 ± 1.3 and 0.6 ± 0.3, respectively; P = 0.004), at 24 h after injection. Conclusion: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.

Original languageEnglish (US)
Pages (from-to)1649-1652
Number of pages4
JournalJournal of Nuclear Medicine
Volume47
Issue number10
StatePublished - Oct 1 2006

Keywords

  • Copper (II)-64 chlorides
  • Human copper transporter 1
  • Positron emission tomography
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'PEt of human prostate cancer xenografts in mice with increased uptake of<sup>64</sup>CuCl<sub>2</sub>'. Together they form a unique fingerprint.

Cite this