PEt of human prostate cancer xenografts in mice with increased uptake of64CuCl2

Fangyu Peng, Xin Lu, James Janisse, Otto Muzik, Anthony F. Shields

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. Results: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gramof tissue: 3.6 ± 1.3 and 0.6 ± 0.3, respectively; P = 0.004), at 24 h after injection. Conclusion: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.

Original languageEnglish (US)
Pages (from-to)1649-1652
Number of pages4
JournalJournal of Nuclear Medicine
Volume47
Issue number10
StatePublished - Oct 1 2006

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Heterografts
Prostatic Neoplasms
Injections
Nude Mice
Neoplasms
Immunohistochemistry
copper transporter 1

Keywords

  • Copper (II)-64 chlorides
  • Human copper transporter 1
  • Positron emission tomography
  • Prostate cancer

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Peng, F., Lu, X., Janisse, J., Muzik, O., & Shields, A. F. (2006). PEt of human prostate cancer xenografts in mice with increased uptake of64CuCl2 Journal of Nuclear Medicine, 47(10), 1649-1652.

PEt of human prostate cancer xenografts in mice with increased uptake of64CuCl2 . / Peng, Fangyu; Lu, Xin; Janisse, James; Muzik, Otto; Shields, Anthony F.

In: Journal of Nuclear Medicine, Vol. 47, No. 10, 01.10.2006, p. 1649-1652.

Research output: Contribution to journalArticle

Peng, F, Lu, X, Janisse, J, Muzik, O & Shields, AF 2006, 'PEt of human prostate cancer xenografts in mice with increased uptake of64CuCl2 ', Journal of Nuclear Medicine, vol. 47, no. 10, pp. 1649-1652.
Peng, Fangyu ; Lu, Xin ; Janisse, James ; Muzik, Otto ; Shields, Anthony F. / PEt of human prostate cancer xenografts in mice with increased uptake of64CuCl2 In: Journal of Nuclear Medicine. 2006 ; Vol. 47, No. 10. pp. 1649-1652.
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