PET [11C]DASB imaging of serotonin transporters in patients with alcoholism

Amira K. Brown, David T. George, Masahiro Fujita, Jeih San Liow, Masanori Ichise, Joseph Hibbeln, Subroto Ghose, Janet Sangare, Daniel Hommer, Robert B. Innis

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics. Methods: Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [11C]-3-amino-4-(2- dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were classified as aggressive or nonaggressive based on a comparison between the top third and bottom third scores on the Buss-Durkee Hostility Index. Results: Using a pixel-wise comparison, no brain region showed significant alterations in SERT binding among the 3 groups of subjects (aggressive alcoholic subjects, nonaggressive alcoholic subjects, and healthy controls) or between the combined alcoholic group and healthy controls. None of the clinical measures (including measures of aggression) correlated with SERT binding in the alcoholic subjects. Conclusion: Contrary to prior imaging reports using the nonselective ligand [123I]β-CIT, we found no significant alterations of SERT density in alcoholic patients.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume31
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Alcoholics
Alcoholism
Imaging techniques
Aggression
Inpatients
Brain
Serotonin
Pixels
Ligands
Hostility
3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile
Synaptic Transmission
Positron-Emission Tomography
Healthy Volunteers
Control Groups

Keywords

  • [ C]DASB
  • Aggression
  • Alcoholism
  • Parametric Imaging
  • Positron Emission Tomography
  • Serotonin Transporter

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Brown, A. K., George, D. T., Fujita, M., Liow, J. S., Ichise, M., Hibbeln, J., ... Innis, R. B. (2007). PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcoholism: Clinical and Experimental Research, 31(1), 28-32. https://doi.org/10.1111/j.1530-0277.2006.00261.x

PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. / Brown, Amira K.; George, David T.; Fujita, Masahiro; Liow, Jeih San; Ichise, Masanori; Hibbeln, Joseph; Ghose, Subroto; Sangare, Janet; Hommer, Daniel; Innis, Robert B.

In: Alcoholism: Clinical and Experimental Research, Vol. 31, No. 1, 01.2007, p. 28-32.

Research output: Contribution to journalArticle

Brown, AK, George, DT, Fujita, M, Liow, JS, Ichise, M, Hibbeln, J, Ghose, S, Sangare, J, Hommer, D & Innis, RB 2007, 'PET [11C]DASB imaging of serotonin transporters in patients with alcoholism', Alcoholism: Clinical and Experimental Research, vol. 31, no. 1, pp. 28-32. https://doi.org/10.1111/j.1530-0277.2006.00261.x
Brown, Amira K. ; George, David T. ; Fujita, Masahiro ; Liow, Jeih San ; Ichise, Masanori ; Hibbeln, Joseph ; Ghose, Subroto ; Sangare, Janet ; Hommer, Daniel ; Innis, Robert B. / PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. In: Alcoholism: Clinical and Experimental Research. 2007 ; Vol. 31, No. 1. pp. 28-32.
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