PET–Computed Tomography and Precision Medicine in Pancreatic Adenocarcinoma and Pancreatic Neuroendocrine Tumors

Daniella F. Pinho; Rathan M. Subramaniam

doi:10.1016/j.cpet.2017.05.003

PET–Computed Tomography and Precision Medicine in Pancreatic Adenocarcinoma and Pancreatic Neuroendocrine Tumors

Daniella F. Pinho, Rathan M. Subramaniam

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

¹⁸F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prognosis. Pancreatic neuroendocrine tumors are rare tumors that originate from the islet cells of the pancreas. Currently, ⁶⁸Ga-DOTA-labeled somatostatin analogs are considered the best modality for detection of well-differentiated neuroendocrine tumors. ¹⁸F-FDG PET/CT has a role in patients with poorly differentiated tumors. Recent studies have demonstrated improved survival in patients with metastatic neuroendocrine tumors treated with radiolabeled somatostatin analogs.

Original language	English (US)
Pages (from-to)	407-421
Number of pages	15
Journal	PET Clinics
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.cpet.2017.05.003
State	Published - Oct 2017

Keywords

PET
PET/CT
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatic neuroendocrine tumor

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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title = "PET–Computed Tomography and Precision Medicine in Pancreatic Adenocarcinoma and Pancreatic Neuroendocrine Tumors",

abstract = "18F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prognosis. Pancreatic neuroendocrine tumors are rare tumors that originate from the islet cells of the pancreas. Currently, 68Ga-DOTA-labeled somatostatin analogs are considered the best modality for detection of well-differentiated neuroendocrine tumors. 18F-FDG PET/CT has a role in patients with poorly differentiated tumors. Recent studies have demonstrated improved survival in patients with metastatic neuroendocrine tumors treated with radiolabeled somatostatin analogs.",

keywords = "PET, PET/CT, Pancreatic adenocarcinoma, Pancreatic cancer, Pancreatic neuroendocrine tumor",

author = "Pinho, {Daniella F.} and Subramaniam, {Rathan M.}",

year = "2017",

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doi = "10.1016/j.cpet.2017.05.003",

language = "English (US)",

volume = "12",

pages = "407--421",

journal = "PET Clinics",

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AU - Pinho, Daniella F.

AU - Subramaniam, Rathan M.

PY - 2017/10

Y1 - 2017/10

N2 - 18F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prognosis. Pancreatic neuroendocrine tumors are rare tumors that originate from the islet cells of the pancreas. Currently, 68Ga-DOTA-labeled somatostatin analogs are considered the best modality for detection of well-differentiated neuroendocrine tumors. 18F-FDG PET/CT has a role in patients with poorly differentiated tumors. Recent studies have demonstrated improved survival in patients with metastatic neuroendocrine tumors treated with radiolabeled somatostatin analogs.

AB - 18F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prognosis. Pancreatic neuroendocrine tumors are rare tumors that originate from the islet cells of the pancreas. Currently, 68Ga-DOTA-labeled somatostatin analogs are considered the best modality for detection of well-differentiated neuroendocrine tumors. 18F-FDG PET/CT has a role in patients with poorly differentiated tumors. Recent studies have demonstrated improved survival in patients with metastatic neuroendocrine tumors treated with radiolabeled somatostatin analogs.

KW - PET

KW - PET/CT

KW - Pancreatic adenocarcinoma

KW - Pancreatic cancer

KW - Pancreatic neuroendocrine tumor

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PET–Computed Tomography and Precision Medicine in Pancreatic Adenocarcinoma and Pancreatic Neuroendocrine Tumors

Abstract

Keywords

ASJC Scopus subject areas

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