PET/CT of dementia

Katherine Zukotynski, Phillip H. Kuo, David Mikulis, Pedro Rosa-Neto, Antonio P. Strafella, Rathan M. Subramaniam, Sandra E. Black

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.

Original languageEnglish (US)
Pages (from-to)246-259
Number of pages14
JournalAmerican Journal of Roentgenology
Volume211
Issue number2
DOIs
StatePublished - Aug 1 2018

Fingerprint

Dementia
Amyloidogenic Proteins
tau Proteins
Fluorine
Standard of Care
Practice Guidelines
Atrophy
Blood Vessels
Glucose
Brain

Keywords

  • Amyloid
  • Dementia
  • Imaging
  • PET/CT
  • Tau

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Zukotynski, K., Kuo, P. H., Mikulis, D., Rosa-Neto, P., Strafella, A. P., Subramaniam, R. M., & Black, S. E. (2018). PET/CT of dementia. American Journal of Roentgenology, 211(2), 246-259. https://doi.org/10.2214/AJR.18.19822

PET/CT of dementia. / Zukotynski, Katherine; Kuo, Phillip H.; Mikulis, David; Rosa-Neto, Pedro; Strafella, Antonio P.; Subramaniam, Rathan M.; Black, Sandra E.

In: American Journal of Roentgenology, Vol. 211, No. 2, 01.08.2018, p. 246-259.

Research output: Contribution to journalArticle

Zukotynski, K, Kuo, PH, Mikulis, D, Rosa-Neto, P, Strafella, AP, Subramaniam, RM & Black, SE 2018, 'PET/CT of dementia', American Journal of Roentgenology, vol. 211, no. 2, pp. 246-259. https://doi.org/10.2214/AJR.18.19822
Zukotynski K, Kuo PH, Mikulis D, Rosa-Neto P, Strafella AP, Subramaniam RM et al. PET/CT of dementia. American Journal of Roentgenology. 2018 Aug 1;211(2):246-259. https://doi.org/10.2214/AJR.18.19822
Zukotynski, Katherine ; Kuo, Phillip H. ; Mikulis, David ; Rosa-Neto, Pedro ; Strafella, Antonio P. ; Subramaniam, Rathan M. ; Black, Sandra E. / PET/CT of dementia. In: American Journal of Roentgenology. 2018 ; Vol. 211, No. 2. pp. 246-259.
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