PET/CT of dementia

Katherine Zukotynski, Phillip H. Kuo, David Mikulis, Pedro Rosa-Neto, Antonio P. Strafella, Rathan M. Subramaniam, Sandra E. Black

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.

Original languageEnglish (US)
Pages (from-to)246-259
Number of pages14
JournalAmerican Journal of Roentgenology
Volume211
Issue number2
DOIs
StatePublished - Aug 1 2018

Keywords

  • Amyloid
  • Dementia
  • Imaging
  • PET/CT
  • Tau

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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