Abstract
OBJECTIVE:: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. STUDY DESIGN:: Retrospective case review, 1995 to 2015. SETTING:: Multicenter study. PATIENTS:: Consecutive patients with histopathologically proven petroclival chondrosarcoma. INTERVENTION(S):: Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. MAIN OUTCOME MEASURES:: Disease- and treatment-associated morbidity, recurrence, mortality. RESULTS:: Fifty-five patients (mean age 42 years; 56% women) presenting with primary or recurrent petroclival chondrosarcoma were analyzed. The mean duration of follow-up was 74 months. Among 47 primary cases, the most common presenting symptoms were headache (55%) and diplopia (49%) and the mean tumor size at diagnosis was 3.3?cm. Subtotal resection was performed in 33 (73%) patients and gross total resection in 12 (27%). Adjuvant postoperative radiation was administered in 30 (64%) cases. Preoperative cranial neuropathy improved in 13 (29%), worsened in 11 (24%), and remained stable in 21 (47%) patients; notably, 11 preoperative sixth nerve palsies resolved after treatment. Nine recurrences occurred at a mean of 42 months. The 1-, 3-, 5- and 10-year recurrence-free survival rate for all 45 patients who underwent primary microsurgery with or without adjuvant radiation therapy was 97%, 89%, 70%, and 56%, respectively. Higher tumor stage, larger categorical size (
| Original language | English (US) |
|---|---|
| Journal | Otology and Neurotology |
| DOIs | |
| State | Accepted/In press - Jun 3 2016 |
Fingerprint
ASJC Scopus subject areas
- Otorhinolaryngology
- Clinical Neurology
- Sensory Systems
Cite this
Petroclival Chondrosarcoma : A Multicenter Review of 55 Cases and New Staging System. / Carlson, Matthew L.; O’Connell, Brendan P.; Breen, Joseph T.; Wick, Cameron C.; Driscoll, Colin L.; Haynes, David S.; Thompson, Reid C.; Isaacson, Brandon; Gidley, Paul W.; Kutz, J. W.; van Gompel, Jamie J.; Wanna, George B.; Raza, Shaan M.; DeMonte, Franco; Barnett, Samuel L.; Link, Michael J.
In: Otology and Neurotology, 03.06.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Petroclival Chondrosarcoma
T2 - A Multicenter Review of 55 Cases and New Staging System
AU - Carlson, Matthew L.
AU - O’Connell, Brendan P.
AU - Breen, Joseph T.
AU - Wick, Cameron C.
AU - Driscoll, Colin L.
AU - Haynes, David S.
AU - Thompson, Reid C.
AU - Isaacson, Brandon
AU - Gidley, Paul W.
AU - Kutz, J. W.
AU - van Gompel, Jamie J.
AU - Wanna, George B.
AU - Raza, Shaan M.
AU - DeMonte, Franco
AU - Barnett, Samuel L.
AU - Link, Michael J.
PY - 2016/6/3
Y1 - 2016/6/3
N2 - OBJECTIVE:: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. STUDY DESIGN:: Retrospective case review, 1995 to 2015. SETTING:: Multicenter study. PATIENTS:: Consecutive patients with histopathologically proven petroclival chondrosarcoma. INTERVENTION(S):: Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. MAIN OUTCOME MEASURES:: Disease- and treatment-associated morbidity, recurrence, mortality. RESULTS:: Fifty-five patients (mean age 42 years; 56% women) presenting with primary or recurrent petroclival chondrosarcoma were analyzed. The mean duration of follow-up was 74 months. Among 47 primary cases, the most common presenting symptoms were headache (55%) and diplopia (49%) and the mean tumor size at diagnosis was 3.3?cm. Subtotal resection was performed in 33 (73%) patients and gross total resection in 12 (27%). Adjuvant postoperative radiation was administered in 30 (64%) cases. Preoperative cranial neuropathy improved in 13 (29%), worsened in 11 (24%), and remained stable in 21 (47%) patients; notably, 11 preoperative sixth nerve palsies resolved after treatment. Nine recurrences occurred at a mean of 42 months. The 1-, 3-, 5- and 10-year recurrence-free survival rate for all 45 patients who underwent primary microsurgery with or without adjuvant radiation therapy was 97%, 89%, 70%, and 56%, respectively. Higher tumor stage, larger categorical size (
AB - OBJECTIVE:: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. STUDY DESIGN:: Retrospective case review, 1995 to 2015. SETTING:: Multicenter study. PATIENTS:: Consecutive patients with histopathologically proven petroclival chondrosarcoma. INTERVENTION(S):: Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. MAIN OUTCOME MEASURES:: Disease- and treatment-associated morbidity, recurrence, mortality. RESULTS:: Fifty-five patients (mean age 42 years; 56% women) presenting with primary or recurrent petroclival chondrosarcoma were analyzed. The mean duration of follow-up was 74 months. Among 47 primary cases, the most common presenting symptoms were headache (55%) and diplopia (49%) and the mean tumor size at diagnosis was 3.3?cm. Subtotal resection was performed in 33 (73%) patients and gross total resection in 12 (27%). Adjuvant postoperative radiation was administered in 30 (64%) cases. Preoperative cranial neuropathy improved in 13 (29%), worsened in 11 (24%), and remained stable in 21 (47%) patients; notably, 11 preoperative sixth nerve palsies resolved after treatment. Nine recurrences occurred at a mean of 42 months. The 1-, 3-, 5- and 10-year recurrence-free survival rate for all 45 patients who underwent primary microsurgery with or without adjuvant radiation therapy was 97%, 89%, 70%, and 56%, respectively. Higher tumor stage, larger categorical size (
UR - http://www.scopus.com/inward/record.url?scp=84973473506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973473506&partnerID=8YFLogxK
U2 - 10.1097/MAO.0000000000001037
DO - 10.1097/MAO.0000000000001037
M3 - Article
C2 - 27273403
AN - SCOPUS:84973473506
JO - Otology and Neurotology
JF - Otology and Neurotology
SN - 1531-7129
ER -