TY - JOUR
T1 - Petroclival Chondrosarcoma
T2 - A Multicenter Review of 55 Cases and New Staging System
AU - Carlson, Matthew L.
AU - O’Connell, Brendan P.
AU - Breen, Joseph T.
AU - Wick, Cameron C.
AU - Driscoll, Colin L.
AU - Haynes, David S.
AU - Thompson, Reid C.
AU - Isaacson, Brandon
AU - Gidley, Paul W.
AU - Kutz, J. W.
AU - van Gompel, Jamie J.
AU - Wanna, George B.
AU - Raza, Shaan M.
AU - DeMonte, Franco
AU - Barnett, Samuel L.
AU - Link, Michael J.
PY - 2016/6/3
Y1 - 2016/6/3
N2 - OBJECTIVE:: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. STUDY DESIGN:: Retrospective case review, 1995 to 2015. SETTING:: Multicenter study. PATIENTS:: Consecutive patients with histopathologically proven petroclival chondrosarcoma. INTERVENTION(S):: Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. MAIN OUTCOME MEASURES:: Disease- and treatment-associated morbidity, recurrence, mortality. RESULTS:: Fifty-five patients (mean age 42 years; 56% women) presenting with primary or recurrent petroclival chondrosarcoma were analyzed. The mean duration of follow-up was 74 months. Among 47 primary cases, the most common presenting symptoms were headache (55%) and diplopia (49%) and the mean tumor size at diagnosis was 3.3?cm. Subtotal resection was performed in 33 (73%) patients and gross total resection in 12 (27%). Adjuvant postoperative radiation was administered in 30 (64%) cases. Preoperative cranial neuropathy improved in 13 (29%), worsened in 11 (24%), and remained stable in 21 (47%) patients; notably, 11 preoperative sixth nerve palsies resolved after treatment. Nine recurrences occurred at a mean of 42 months. The 1-, 3-, 5- and 10-year recurrence-free survival rate for all 45 patients who underwent primary microsurgery with or without adjuvant radiation therapy was 97%, 89%, 70%, and 56%, respectively. Higher tumor stage, larger categorical size (
AB - OBJECTIVE:: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. STUDY DESIGN:: Retrospective case review, 1995 to 2015. SETTING:: Multicenter study. PATIENTS:: Consecutive patients with histopathologically proven petroclival chondrosarcoma. INTERVENTION(S):: Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. MAIN OUTCOME MEASURES:: Disease- and treatment-associated morbidity, recurrence, mortality. RESULTS:: Fifty-five patients (mean age 42 years; 56% women) presenting with primary or recurrent petroclival chondrosarcoma were analyzed. The mean duration of follow-up was 74 months. Among 47 primary cases, the most common presenting symptoms were headache (55%) and diplopia (49%) and the mean tumor size at diagnosis was 3.3?cm. Subtotal resection was performed in 33 (73%) patients and gross total resection in 12 (27%). Adjuvant postoperative radiation was administered in 30 (64%) cases. Preoperative cranial neuropathy improved in 13 (29%), worsened in 11 (24%), and remained stable in 21 (47%) patients; notably, 11 preoperative sixth nerve palsies resolved after treatment. Nine recurrences occurred at a mean of 42 months. The 1-, 3-, 5- and 10-year recurrence-free survival rate for all 45 patients who underwent primary microsurgery with or without adjuvant radiation therapy was 97%, 89%, 70%, and 56%, respectively. Higher tumor stage, larger categorical size (
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U2 - 10.1097/MAO.0000000000001037
DO - 10.1097/MAO.0000000000001037
M3 - Article
C2 - 27273403
AN - SCOPUS:84973473506
JO - Otology and Neurotology
JF - Otology and Neurotology
SN - 1531-7129
ER -