PGC1α in the kidney

Matthew R. Lynch, Mei T. Tran, Samir M. Parikh

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1 α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal effects of PGC1 α make it a prime target for therapeutics aimed at ameliorating AKI, forms of chronic kidney disease (CKD), and their intersection. This review summarizes the current literature on the relationship between renal health and PGC1 α and proposes areas of future interest.

Original languageEnglish (US)
Pages (from-to)F1-F8
JournalAmerican Journal of Physiology - Renal Physiology
Volume314
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

Keywords

  • AKI
  • CKD
  • Kidney
  • Metabolism
  • PGC1α

ASJC Scopus subject areas

  • Physiology
  • Urology

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