pH-Controlled selective protection of polyaza macrocycles

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Piperazine (1), tetraazacyclododecane 3 and pentaazacyclopentadecane 4 react with chloroformates in acid solution to give the selectively protected carbamate derivatives 1a,3a-d, and 4a. The benzyloxycarbonyl derivatives 3d and 4a were alkylated with tertbutyl bromoacetate and removal of the benzyloxycarbonyl protection by catalytic hydrogenation afforded tert-butyl esters 5b and 6b in good yields.

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalSynthesis
Issue number7
StatePublished - 1997

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Derivatives
Carbamates
Hydrogenation
Esters
Acids
piperazine
bromoacetate

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

pH-Controlled selective protection of polyaza macrocycles. / Kovacs, Zoltan; Sherry, A. Dean.

In: Synthesis, No. 7, 1997, p. 759-763.

Research output: Contribution to journalArticle

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