PH-responsive theranostic polymer-caged nanobins: Enhanced cytotoxicity and T1 MRI contrast by Her2 targeting

Bong Jin Hong, Elden P. Swindell, Keith W. MacRenaris, Patrick L. Hankins, Anthony J. Chipre, Daniel J. Mastarone, Richard W. Ahn, Thomas J. Meade, Thomas V. O'Halloran, Sonbinh T. Nguyen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and GdIII-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular GdIII uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.

Original languageEnglish (US)
Pages (from-to)770-774
Number of pages5
JournalParticle and Particle Systems Characterization
Issue number9
StatePublished - Sep 2013
Externally publishedYes


  • cancer targeting
  • drug delivery
  • magnetic resonance imaging
  • pH-responsive drug release
  • theranostics

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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