Pharmacokinetic modeling of dynamic MR images using a simulated annealing based optimization

Amit Sawant, John H. Reece, Wilburn E. Reddick

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The aim of this work was to use dynamic contrast enhanced MR image (DEMRI) data to generate `parameter images' which provide functional information about contrast agent access, in bone sarcoma. A simulated annealing based technique was applied to optimize the parameters of a pharmacokinetic model used to describe the kinetics of the tissue response during and after intravenous infusion of a paramagnetic contrast medium, Gd-DTPA. Optimization was performed on a pixel by pixel basis so as to minimize the sum of square deviations of the calculated values from the values obtained experimentally during dynamic contrast enhanced MR imaging. A cost function based on a priori information was introduced during the annealing procedure to ensure that the values obtained were within the expected ranges. The optimized parameters were used in the model to generate parameter images, which reveal functional information that is normally not visible in conventional Gd-DTPA enhanced MR images. This functional information, during and upon completion of pre-operative chemotherapy, is useful in predicting the probability of disease free survival.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages276-283
Number of pages8
Volume3978
StatePublished - 2000
EventMedical Imaging 2000: Physiology and Function from Multidimensional Images - San Diego, CA, USA
Duration: Feb 13 2000Feb 15 2000

Other

OtherMedical Imaging 2000: Physiology and Function from Multidimensional Images
CitySan Diego, CA, USA
Period2/13/002/15/00

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    Sawant, A., Reece, J. H., & Reddick, W. E. (2000). Pharmacokinetic modeling of dynamic MR images using a simulated annealing based optimization. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3978, pp. 276-283). Society of Photo-Optical Instrumentation Engineers.