Pharmacokinetics and antibacterial efficacy of cefpirome (HR 810) in experimental Escherichia coli and Haemophilus influenzae type b meningitis

H. S. Jafari, X. Saez-Llorens, O. Ramilo, S. L. Shelton, G. H. McCracken

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Abstract

Cefpirome (HR 810) is a new cephalosporin related to cefotaxime that has potent bactericidal activity against a broad spectrum of gram-negative and gram-positive organisms. The pharmacokinetics and bacteriological efficacy of cefpirome administered as a single intravenous dose were assessed in rabbits with experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. The mean penetrations into the cerebrospinal fluid (CSF) in relation to the amount of drug in serum of animals infected with H. influenzae and E. coli were 25 and 54%, respectively. The median CSF bactericidal titers were 1:128 against both organisms at 1 h after the dose and 1:32 and 1:16 against H. influenzae and E. coli, respectively, at 8 h after the dose. In CSF of uninfected animals, the mean penetration was 4.5%. There was a significant reduction in the concentrations of bacteria in CSFs of both groups of animals treated with cefpirome compared with that in untreated groups. Mortality was also significantly lower in treated animals than it was in untreated animals. Intravenous administration of dexamethasone before the cefpirome dose did not compromise penetration, bactericidal titers, or antibacterial activity of cefpirome in CSF.

Original languageEnglish (US)
Pages (from-to)220-223
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number2
StatePublished - 1991

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cefpirome
Haemophilus influenzae type b
Meningitis
Pharmacokinetics
Escherichia coli
Cerebrospinal Fluid
Haemophilus influenzae
Escherichia coli Meningitis
Cefotaxime
Cephalosporins
Intravenous Administration
Dexamethasone

ASJC Scopus subject areas

  • Pharmacology (medical)

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Pharmacokinetics and antibacterial efficacy of cefpirome (HR 810) in experimental Escherichia coli and Haemophilus influenzae type b meningitis. / Jafari, H. S.; Saez-Llorens, X.; Ramilo, O.; Shelton, S. L.; McCracken, G. H.

In: Antimicrobial Agents and Chemotherapy, Vol. 35, No. 2, 1991, p. 220-223.

Research output: Contribution to journalArticle

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