TY - JOUR
T1 - Pharmacokinetics and bactericidal activity of sultamicillin in infants and children
AU - Ginsbarg, Charles M.
AU - Mccracken, George H.
AU - Olsen, Kurt
AU - Petrutska, Mary
N1 - Funding Information:
Acknowledgements by a grant from Pfizer Pharmaceuticals.
PY - 1985/3
Y1 - 1985/3
N2 - The pharmacokinetics of sultarnicillin and ampicillin suspensions were studled in 20 infants and children 8 months to 69 months of age (mean age, 27 months). Mean peak plasma concentrations of ampicillin and sulbactam occurred at 90 minutes after administration of 42.5 mg of sultamicillin (25 mg of ampicillin/kg and 17 5 mg of sulbactam/kg) per kg to fasting and non-fasting patients. Coadmnistration of milk usually resulted in higher concentrations of ampicillin and sulbactam, however, the differences in the AUC values between the fasting and fed groups were not statistically significant. Sultamicillin and ampicillin were administered In cross-over fashion to ten children Plasma concentrations of ampicillin after 42.5 mg of sultamicillin per kg were greater at 20, 40, and 60 min than those after 25 mg of ampicillin per kg alone and the AUC was 39% larger in subjects who received sultamicillin than in those who received ampicillin. Plasma bacteriadal activity against a non-β-lactamase produang Haemophilus influenzaestrain was similar for children who were given sultamicillin or ampicillin. Against a β-lactamase-producing Haemophilus strain the median bactericidal titres were 1:8 at 40, 60 and 90 min after sultamicillin and < 1:2 at the same intervals after ampicillin.
AB - The pharmacokinetics of sultarnicillin and ampicillin suspensions were studled in 20 infants and children 8 months to 69 months of age (mean age, 27 months). Mean peak plasma concentrations of ampicillin and sulbactam occurred at 90 minutes after administration of 42.5 mg of sultamicillin (25 mg of ampicillin/kg and 17 5 mg of sulbactam/kg) per kg to fasting and non-fasting patients. Coadmnistration of milk usually resulted in higher concentrations of ampicillin and sulbactam, however, the differences in the AUC values between the fasting and fed groups were not statistically significant. Sultamicillin and ampicillin were administered In cross-over fashion to ten children Plasma concentrations of ampicillin after 42.5 mg of sultamicillin per kg were greater at 20, 40, and 60 min than those after 25 mg of ampicillin per kg alone and the AUC was 39% larger in subjects who received sultamicillin than in those who received ampicillin. Plasma bacteriadal activity against a non-β-lactamase produang Haemophilus influenzaestrain was similar for children who were given sultamicillin or ampicillin. Against a β-lactamase-producing Haemophilus strain the median bactericidal titres were 1:8 at 40, 60 and 90 min after sultamicillin and < 1:2 at the same intervals after ampicillin.
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U2 - 10.1093/jac/15.3.345
DO - 10.1093/jac/15.3.345
M3 - Article
C2 - 2987174
AN - SCOPUS:0021969754
SN - 0305-7453
VL - 15
SP - 345
EP - 351
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 3
ER -