Pharmacokinetics and bacteriological efficacy of ticarcillin-clavulanic acid (Timentin) in experimental Escherichia coli K-1 and haemophilus influenzae type b meningitis

G. A. Syrogiannopoulos, A. Al-Sabbagh, K. D. Olsen, G. H. McCracken

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Abstract

The pharmacokinetics and bacteriological efficacy of ticarcillin and clavulanic acid administered individually or in combination were assessed in rabbits with experimental Escherichia coli K-1 and Haemophilus influenzae type b meningitis. The mean penetrations into the cerebrospinal fluid (CSF) of infected animals after a single dose of ticarcillin-clavulanic acid were approximately 11 and 28% for ticarcillin and clavulanic acid, respectively. In continuous-infusion experiments, the mean penetrations into CSF were 14.6 and 35% for ticarcillin and clavulanic acid, respectively, in rabbits with E. coli meningitis and 6.1 and 24%, respectively, in rabbits with H. influenzae meningitis. In animals that received a continuous infusion of the two drugs alone or in combination, the median CSF bactericidal titers for E. coli were <1:2, <1:2, and 1:2 for ticarcillin, clavulanic acid, and ticarcillin-clavulanic acid, respectively, and for H. influenzae the titers were <1:2, <1:2, and 1:4, respectively. The addition of clavulanic acid potentiated significantly the bacteriological efficacy of ticarcillin in reducing the number of bacteria in CSF of infected rabbits. Additional studies in animals and humans are required before recommendations can be made regarding the use of ticarcillin-clavulanic acid for treatment of meningitis.

Original languageEnglish (US)
Pages (from-to)1296-1300
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume31
Issue number9
StatePublished - 1987

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Haemophilus influenzae type b
Meningitis
Pharmacokinetics
Escherichia coli
Cerebrospinal Fluid
Rabbits
Haemophilus influenzae
Escherichia coli Meningitis
Haemophilus Meningitis
Ticarcillin
Clavulanic Acid
ticarcillin-clavulanic acid
Bacteria
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Pharmacokinetics and bacteriological efficacy of ticarcillin-clavulanic acid (Timentin) in experimental Escherichia coli K-1 and haemophilus influenzae type b meningitis. / Syrogiannopoulos, G. A.; Al-Sabbagh, A.; Olsen, K. D.; McCracken, G. H.

In: Antimicrobial Agents and Chemotherapy, Vol. 31, No. 9, 1987, p. 1296-1300.

Research output: Contribution to journalArticle

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abstract = "The pharmacokinetics and bacteriological efficacy of ticarcillin and clavulanic acid administered individually or in combination were assessed in rabbits with experimental Escherichia coli K-1 and Haemophilus influenzae type b meningitis. The mean penetrations into the cerebrospinal fluid (CSF) of infected animals after a single dose of ticarcillin-clavulanic acid were approximately 11 and 28{\%} for ticarcillin and clavulanic acid, respectively. In continuous-infusion experiments, the mean penetrations into CSF were 14.6 and 35{\%} for ticarcillin and clavulanic acid, respectively, in rabbits with E. coli meningitis and 6.1 and 24{\%}, respectively, in rabbits with H. influenzae meningitis. In animals that received a continuous infusion of the two drugs alone or in combination, the median CSF bactericidal titers for E. coli were <1:2, <1:2, and 1:2 for ticarcillin, clavulanic acid, and ticarcillin-clavulanic acid, respectively, and for H. influenzae the titers were <1:2, <1:2, and 1:4, respectively. The addition of clavulanic acid potentiated significantly the bacteriological efficacy of ticarcillin in reducing the number of bacteria in CSF of infected rabbits. Additional studies in animals and humans are required before recommendations can be made regarding the use of ticarcillin-clavulanic acid for treatment of meningitis.",
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