Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis

M. Del Rio, G. H. McCracken, J. D. Nelson, D. Chrane, S. Shelton

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Abstract

Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1%. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.

Original languageEnglish (US)
Pages (from-to)622-627
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume22
Issue number4
StatePublished - 1982

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Bacterial Meningitides
Ceftriaxone
Cerebrospinal Fluid
Pharmacokinetics
Pediatrics
Therapeutics
Half-Life
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

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abstract = "Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1{\%}. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.",
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AU - Del Rio, M.

AU - McCracken, G. H.

AU - Nelson, J. D.

AU - Chrane, D.

AU - Shelton, S.

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N2 - Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1%. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.

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