Abstract
Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1%. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 622-627 |
| Number of pages | 6 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 22 |
| Issue number | 4 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis. / Del Rio, M.; McCracken, G. H.; Nelson, J. D.; Chrane, D.; Shelton, S.
In: Antimicrobial Agents and Chemotherapy, Vol. 22, No. 4, 1982, p. 622-627.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis
AU - Del Rio, M.
AU - McCracken, G. H.
AU - Nelson, J. D.
AU - Chrane, D.
AU - Shelton, S.
PY - 1982
Y1 - 1982
N2 - Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1%. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.
AB - Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1%. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.
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M3 - Article
C2 - 6295262
AN - SCOPUS:0020449995
VL - 22
SP - 622
EP - 627
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 4
ER -