Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis

M. Del Rio, G. H. McCracken, J. D. Nelson, D. Chrane, S. Shelton

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Single-dose pharmacokinetics of ceftriaxone were determined in 19 patients with proven bacterial meningitis. The dosage was 50 mg of ceftriaxone per kg. The plasma concentration time curve declined in a biexponential manner. The mean peak plasma concentration was 207 μg/ml, and the elimination half-life was 4 h. In 12 patients, multiple-dose pharmacokinetics were determined after a loading dose of 75 mg of ceftriaxone per kg, followed by 50-mg/kg doses every 8 h in 5 patients or every 12 h in 7 patients. The mean peak plasma concentration was 230 μg/ml after the first dose and 263 μg/ml after the last dose. Of 12 patients, 5 had trough values that were larger after multiple doses than after a single dose. Mean penetration of ceftriaxone into cerebrospinal fluid was 3.1%. The median cerebrospinal fluid bacterial titer against the patients pathogens was >1:1,024 and <1:2,048. The drug was well tolerated without adverse effects.

Original languageEnglish (US)
Pages (from-to)622-627
Number of pages6
JournalUnknown Journal
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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