Pharmacokinetics of cefaclor in infants and children

George H. Mccracken, Charles M. Ginsburg, Joan C. Clahsen, Marion L. Thomas

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The pharmacokinetics of cefaclor were studied in 28 infants and children. Serum concentrations of 10.8 μg/ml and 13.1 μg/ml were observed in fasting patients 30min after 10 and 15 mg/kg doses, respectively. Although peak concentrations were smaller in children given drug and milk concomitantly, the area-under-the-curve values were not affected. Average half-life values ranged from 36 to 60 min; shorter times were observed with 15 mg/kg doses. The mean concentrations of cefaclor in saliva at 2,4 and 6 h after 15 mg/kg doses were similar to those in serum. The levels in tears were > 1.0 μg/ml in 7 of 8 samples obtained 2 h after the dose. These pharmacokinetic properties of cefaclor were compared to those of cephalexin in comparably aged patients.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume4
Issue number6
DOIs
StatePublished - Nov 1978

Fingerprint

Cefaclor
Pharmacokinetics
Dose
Cephalexin
Serum
Tears
Saliva
Area Under Curve
Half-Life
Fasting
Milk
Drugs
Pharmaceutical Preparations
Curve
Children
Half-life

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Microbiology

Cite this

Pharmacokinetics of cefaclor in infants and children. / Mccracken, George H.; Ginsburg, Charles M.; Clahsen, Joan C.; Thomas, Marion L.

In: Journal of Antimicrobial Chemotherapy, Vol. 4, No. 6, 11.1978, p. 515-521.

Research output: Contribution to journalArticle

@article{fc92ca6313094651b73fbeccda067b8f,
title = "Pharmacokinetics of cefaclor in infants and children",
abstract = "The pharmacokinetics of cefaclor were studied in 28 infants and children. Serum concentrations of 10.8 μg/ml and 13.1 μg/ml were observed in fasting patients 30min after 10 and 15 mg/kg doses, respectively. Although peak concentrations were smaller in children given drug and milk concomitantly, the area-under-the-curve values were not affected. Average half-life values ranged from 36 to 60 min; shorter times were observed with 15 mg/kg doses. The mean concentrations of cefaclor in saliva at 2,4 and 6 h after 15 mg/kg doses were similar to those in serum. The levels in tears were > 1.0 μg/ml in 7 of 8 samples obtained 2 h after the dose. These pharmacokinetic properties of cefaclor were compared to those of cephalexin in comparably aged patients.",
author = "Mccracken, {George H.} and Ginsburg, {Charles M.} and Clahsen, {Joan C.} and Thomas, {Marion L.}",
year = "1978",
month = "11",
doi = "10.1093/jac/4.6.515",
language = "English (US)",
volume = "4",
pages = "515--521",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Pharmacokinetics of cefaclor in infants and children

AU - Mccracken, George H.

AU - Ginsburg, Charles M.

AU - Clahsen, Joan C.

AU - Thomas, Marion L.

PY - 1978/11

Y1 - 1978/11

N2 - The pharmacokinetics of cefaclor were studied in 28 infants and children. Serum concentrations of 10.8 μg/ml and 13.1 μg/ml were observed in fasting patients 30min after 10 and 15 mg/kg doses, respectively. Although peak concentrations were smaller in children given drug and milk concomitantly, the area-under-the-curve values were not affected. Average half-life values ranged from 36 to 60 min; shorter times were observed with 15 mg/kg doses. The mean concentrations of cefaclor in saliva at 2,4 and 6 h after 15 mg/kg doses were similar to those in serum. The levels in tears were > 1.0 μg/ml in 7 of 8 samples obtained 2 h after the dose. These pharmacokinetic properties of cefaclor were compared to those of cephalexin in comparably aged patients.

AB - The pharmacokinetics of cefaclor were studied in 28 infants and children. Serum concentrations of 10.8 μg/ml and 13.1 μg/ml were observed in fasting patients 30min after 10 and 15 mg/kg doses, respectively. Although peak concentrations were smaller in children given drug and milk concomitantly, the area-under-the-curve values were not affected. Average half-life values ranged from 36 to 60 min; shorter times were observed with 15 mg/kg doses. The mean concentrations of cefaclor in saliva at 2,4 and 6 h after 15 mg/kg doses were similar to those in serum. The levels in tears were > 1.0 μg/ml in 7 of 8 samples obtained 2 h after the dose. These pharmacokinetic properties of cefaclor were compared to those of cephalexin in comparably aged patients.

UR - http://www.scopus.com/inward/record.url?scp=0018165803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018165803&partnerID=8YFLogxK

U2 - 10.1093/jac/4.6.515

DO - 10.1093/jac/4.6.515

M3 - Article

VL - 4

SP - 515

EP - 521

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 6

ER -