Abstract
The pharmacokinetics of cefaclor were studied in 28 infants and children. Serum concentrations of 10.8 μg/ml and 13.1 μg/ml were observed in fasting patients 30min after 10 and 15 mg/kg doses, respectively. Although peak concentrations were smaller in children given drug and milk concomitantly, the area-under-the-curve values were not affected. Average half-life values ranged from 36 to 60 min; shorter times were observed with 15 mg/kg doses. The mean concentrations of cefaclor in saliva at 2,4 and 6 h after 15 mg/kg doses were similar to those in serum. The levels in tears were > 1.0 μg/ml in 7 of 8 samples obtained 2 h after the dose. These pharmacokinetic properties of cefaclor were compared to those of cephalexin in comparably aged patients.
Original language | English (US) |
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Pages (from-to) | 515-521 |
Number of pages | 7 |
Journal | Journal of Antimicrobial Chemotherapy |
Volume | 4 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1978 |
ASJC Scopus subject areas
- Pharmacology
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)