Pharmacokinetics of cefaclor in infants and children

George H. Mccracken, Charles M. Ginsburg, Joan C. Clahsen, Marion L. Thomas

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The pharmacokinetics of cefaclor were studied in 28 infants and children. Serum concentrations of 10.8 μg/ml and 13.1 μg/ml were observed in fasting patients 30min after 10 and 15 mg/kg doses, respectively. Although peak concentrations were smaller in children given drug and milk concomitantly, the area-under-the-curve values were not affected. Average half-life values ranged from 36 to 60 min; shorter times were observed with 15 mg/kg doses. The mean concentrations of cefaclor in saliva at 2,4 and 6 h after 15 mg/kg doses were similar to those in serum. The levels in tears were > 1.0 μg/ml in 7 of 8 samples obtained 2 h after the dose. These pharmacokinetic properties of cefaclor were compared to those of cephalexin in comparably aged patients.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume4
Issue number6
DOIs
StatePublished - Nov 1 1978

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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