Pharmacokinetics of cefotaxime in newborn infants

G. H. McCracken, N. E. Threlkeld, M. L. Thomas

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 μg/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23 and 44 ml/min per 1.73 m2, respectively. A dosage schedule for cefotaxime in newborn infants is presented.

Original languageEnglish (US)
Pages (from-to)683-684
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume21
Issue number4
StatePublished - 1982

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Cefotaxime
Pharmacokinetics
Newborn Infant
Low Birth Weight Infant
Serum
Intravenous Infusions
Appointments and Schedules

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Pharmacokinetics of cefotaxime in newborn infants. / McCracken, G. H.; Threlkeld, N. E.; Thomas, M. L.

In: Antimicrobial Agents and Chemotherapy, Vol. 21, No. 4, 1982, p. 683-684.

Research output: Contribution to journalArticle

McCracken, GH, Threlkeld, NE & Thomas, ML 1982, 'Pharmacokinetics of cefotaxime in newborn infants', Antimicrobial Agents and Chemotherapy, vol. 21, no. 4, pp. 683-684.
McCracken, G. H. ; Threlkeld, N. E. ; Thomas, M. L. / Pharmacokinetics of cefotaxime in newborn infants. In: Antimicrobial Agents and Chemotherapy. 1982 ; Vol. 21, No. 4. pp. 683-684.
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