Abstract
The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 μg/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23 and 44 ml/min per 1.73 m2, respectively. A dosage schedule for cefotaxime in newborn infants is presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-684 |
| Number of pages | 2 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1982 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases