Pharmacokinetics of cefotaxime in newborn infants

G. H. McCracken, N. E. Threlkeld, M. L. Thomas

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 μg/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23 and 44 ml/min per 1.73 m2, respectively. A dosage schedule for cefotaxime in newborn infants is presented.

Original languageEnglish (US)
Pages (from-to)683-684
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume21
Issue number4
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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