Pharmacokinetics of ceftazidime in newborn infants

G. H. McCracken, N. Threlkeld, M. L. Thomas

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Doses of 50 mg of ceftazidime per kg were administered intravenously to 29 newborn infants every 8 or 12 h for 3 to 5 days. Mean peak concentrations in plasma ranged from 102 to 124 μg/ml. Mean elimination half-life values ranged from 2.9 to 6.7 h and varied inversely with gestational age and plasma clearances. Peak and trough plasma bactericidal titers against an Escherichia coli and a group B streptococcus strain were at least 1:16 and 1:32, respectively.

Original languageEnglish (US)
Pages (from-to)583-584
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume26
Issue number4
StatePublished - 1984

Fingerprint

Ceftazidime
Pharmacokinetics
Newborn Infant
Streptococcus agalactiae
Gestational Age
Half-Life
Escherichia coli

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Pharmacokinetics of ceftazidime in newborn infants. / McCracken, G. H.; Threlkeld, N.; Thomas, M. L.

In: Antimicrobial Agents and Chemotherapy, Vol. 26, No. 4, 1984, p. 583-584.

Research output: Contribution to journalArticle

McCracken, GH, Threlkeld, N & Thomas, ML 1984, 'Pharmacokinetics of ceftazidime in newborn infants', Antimicrobial Agents and Chemotherapy, vol. 26, no. 4, pp. 583-584.
McCracken, G. H. ; Threlkeld, N. ; Thomas, M. L. / Pharmacokinetics of ceftazidime in newborn infants. In: Antimicrobial Agents and Chemotherapy. 1984 ; Vol. 26, No. 4. pp. 583-584.
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