Pharmacokinetics of ceftazidime in newborn infants

G. H. McCracken, N. Threlkeld, M. L. Thomas

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Doses of 50 mg of ceftazidime per kg were administered intravenously to 29 newborn infants every 8 or 12 h for 3 to 5 days. Mean peak concentrations in plasma ranged from 102 to 124 μg/ml. Mean elimination half-life values ranged from 2.9 to 6.7 h and varied inversely with gestational age and plasma clearances. Peak and trough plasma bactericidal titers against an Escherichia coli and a group B streptococcus strain were at least 1:16 and 1:32, respectively.

Original languageEnglish (US)
Pages (from-to)583-584
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume26
Issue number4
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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