Pharmacokinetics of clozapine and risperidone: A review of recent literature

Matthew J. Byerly, C. Lindsay DeVane

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The current literature describing the pharmacokinetics of the atypical antipsychotics clozapine and risperidone is reviewed, and discussion on the clinical significance of these data is presented. These drugs are well absorbed when taken orally but are poorly bioavailable because of presystemic elimination. They are highly cleared by hepatic metabolism involving specific P460 isozymes. Risperidone elimination produces a potent active metabolite. Neither of the drugs has received extensive study related to drug-drug interactions, but several are potentially important because a purported therapeutic plasma concentration range is proposed for clozapine and a possible curvilinear dose response relationship has been reported for risperidone. The current clinical pharmacokinetic database for these atypical antipsychotics suggests that much can be learned with additional study that would be of value in individualizing their dosage regimens.

Original languageEnglish (US)
Pages (from-to)177-187
Number of pages11
JournalJournal of Clinical Psychopharmacology
Volume16
Issue number2
DOIs
StatePublished - 1996

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Risperidone
Clozapine
Pharmacokinetics
Antipsychotic Agents
Pharmaceutical Preparations
Drug Interactions
Isoenzymes
Databases
Liver
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pharmacokinetics of clozapine and risperidone : A review of recent literature. / Byerly, Matthew J.; DeVane, C. Lindsay.

In: Journal of Clinical Psychopharmacology, Vol. 16, No. 2, 1996, p. 177-187.

Research output: Contribution to journalArticle

Byerly, Matthew J. ; DeVane, C. Lindsay. / Pharmacokinetics of clozapine and risperidone : A review of recent literature. In: Journal of Clinical Psychopharmacology. 1996 ; Vol. 16, No. 2. pp. 177-187.
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