Pharmacologic atrial natriuretic pep tide reduces human leg capillary filtration

Donald E. Watenpaugh, Susanne F. Vissing, Lynda D. Lane, Jay C. Buckey, Brain G. Firth, William Erdman, Alan R. Hargens, Gunnar G. Blomqvist

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Atrial natriuretic peptide (ANP) is produced and secreted by atrial cells. We measured calf capillary filtration rate with prolonged venous-occlusion plethysmography of supine healthy male subjects during pharmacologic infusion of ANP (48 pmol/kg/min for 15 min; n = 6) and during placebo infusion (n = 7). Results during infusions were compared to prior control measurements. ANP infusion increased plasma [ANP] from 30 ± 4 to 2,568 ± 595 pmol/L. Systemic hemoconcentration occurred during ANP infusion: Mean hematocrit and plasma colloid osmotic pressure increased 4.6 and 11.3%, respectively, relative to preinfusion baseline values (p < 0.05). Mean calf filtration, however, was significantly reduced from 0.15 to 0.08 ml/100 ml/min with ANP. Heart rate increased 20% with ANP infusion, whereas blood pressure was unchanged. Calf conductance (blood flow/arterial pressure) and venous compliance were unaffected by ANP infusion. Placebo infusion had no effect relative to prior baseline control measurements. Although ANP induced systemic capillary filtration, in the calf, filtration was reduced with ANP. Therefore, pharmacologic ANP infusion enhances capillary filtration from the systemic circulation, perhaps at upper body or splanchnic sites or both, while having the opposite effect in the leg.

Original languageEnglish (US)
Pages (from-to)414-419
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume26
Issue number3
StatePublished - 1995

Fingerprint

Atrial Natriuretic Factor
Leg
Placebos
Plethysmography
Viscera
Osmotic Pressure
Colloids
Hematocrit
Compliance
Healthy Volunteers
Arterial Pressure
Heart Rate
Blood Pressure

Keywords

  • Capillary permeability
  • Capillary pressure
  • Extracellular fluid
  • Hemoconcentration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Watenpaugh, D. E., Vissing, S. F., Lane, L. D., Buckey, J. C., Firth, B. G., Erdman, W., ... Blomqvist, G. G. (1995). Pharmacologic atrial natriuretic pep tide reduces human leg capillary filtration. Journal of Cardiovascular Pharmacology, 26(3), 414-419.

Pharmacologic atrial natriuretic pep tide reduces human leg capillary filtration. / Watenpaugh, Donald E.; Vissing, Susanne F.; Lane, Lynda D.; Buckey, Jay C.; Firth, Brain G.; Erdman, William; Hargens, Alan R.; Blomqvist, Gunnar G.

In: Journal of Cardiovascular Pharmacology, Vol. 26, No. 3, 1995, p. 414-419.

Research output: Contribution to journalArticle

Watenpaugh, DE, Vissing, SF, Lane, LD, Buckey, JC, Firth, BG, Erdman, W, Hargens, AR & Blomqvist, GG 1995, 'Pharmacologic atrial natriuretic pep tide reduces human leg capillary filtration', Journal of Cardiovascular Pharmacology, vol. 26, no. 3, pp. 414-419.
Watenpaugh DE, Vissing SF, Lane LD, Buckey JC, Firth BG, Erdman W et al. Pharmacologic atrial natriuretic pep tide reduces human leg capillary filtration. Journal of Cardiovascular Pharmacology. 1995;26(3):414-419.
Watenpaugh, Donald E. ; Vissing, Susanne F. ; Lane, Lynda D. ; Buckey, Jay C. ; Firth, Brain G. ; Erdman, William ; Hargens, Alan R. ; Blomqvist, Gunnar G. / Pharmacologic atrial natriuretic pep tide reduces human leg capillary filtration. In: Journal of Cardiovascular Pharmacology. 1995 ; Vol. 26, No. 3. pp. 414-419.
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