Pharmacological enhancement of aural habilitation in adult cochlear implant users

Emily A. Tobey, Michael D. Devous, Kristi Buckley, Gary Overson, Thomas Harris, Wendy Ringe, Julie Martinez-Verhoff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: The purpose of this report was to examine the preliminary data collected under a larger on-going feasibility study conducted with cochlear implant patients exploring the potential benefit of pharmacologically-enhanced aural rehabilitation therapy as a means of increasing speech tracking skills. Design: Eight adult cochlear implant participants participated in a randomized, double-blind study and received either 10 mg d-amphetamine (Treatment group, N = 4) or a placebo (Placebo group, N = 4) 60 minutes prior to a 1.5 hour intensive aural rehabilitation session occurring twice a week for two months. Treatment consisted of a multi-step rehabilitation program individualized for each participant to develop auditory-only speech tracking skills. Prior to and at the conclusion of the therapy sessions, SPECT rCBF imaging and speech tracking assessments were conducted. Results: Speech tracking scores of the placebo and treatment groups were similar before the aural habilitation intervention. In the placebo group, speech tracking performance increased 13.5% for visual plus auditory and auditory only presentations as a function of aural habilitation alone. The 10 mg d-amphetamine-facilitated program resulted in minimal increases in visual plus auditory tracking scores (2%) but led to a 43% increase for auditory-only speech tracking. Regional cerebral blood flow measures indicated no substantial improvement of brain activation in the placebo group while both the extent and magnitude of primary and associative auditory cortex activations increased significantly with the pharmacologically enhanced treatment program. Conclusions: These data support previous studies indicating an accelerated acquisition of speech and language abilities in stroke patients receiving traditional speech therapy in combination with d-amphetamine. Data, however, are preliminary and further study is warranted.

Original languageEnglish (US)
JournalEar and Hearing
Volume26
Issue number4 SUPPL.
StatePublished - Aug 2005

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Correction of Hearing Impairment
Cochlear Implants
Pharmacology
Dextroamphetamine
Placebos
Cerebrovascular Circulation
Therapeutics
Speech Therapy
Auditory Cortex
Aptitude
Regional Blood Flow
Feasibility Studies
Single-Photon Emission-Computed Tomography
Double-Blind Method
Language
Rehabilitation
Stroke

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Tobey, E. A., Devous, M. D., Buckley, K., Overson, G., Harris, T., Ringe, W., & Martinez-Verhoff, J. (2005). Pharmacological enhancement of aural habilitation in adult cochlear implant users. Ear and Hearing, 26(4 SUPPL.).

Pharmacological enhancement of aural habilitation in adult cochlear implant users. / Tobey, Emily A.; Devous, Michael D.; Buckley, Kristi; Overson, Gary; Harris, Thomas; Ringe, Wendy; Martinez-Verhoff, Julie.

In: Ear and Hearing, Vol. 26, No. 4 SUPPL., 08.2005.

Research output: Contribution to journalArticle

Tobey, EA, Devous, MD, Buckley, K, Overson, G, Harris, T, Ringe, W & Martinez-Verhoff, J 2005, 'Pharmacological enhancement of aural habilitation in adult cochlear implant users', Ear and Hearing, vol. 26, no. 4 SUPPL..
Tobey EA, Devous MD, Buckley K, Overson G, Harris T, Ringe W et al. Pharmacological enhancement of aural habilitation in adult cochlear implant users. Ear and Hearing. 2005 Aug;26(4 SUPPL.).
Tobey, Emily A. ; Devous, Michael D. ; Buckley, Kristi ; Overson, Gary ; Harris, Thomas ; Ringe, Wendy ; Martinez-Verhoff, Julie. / Pharmacological enhancement of aural habilitation in adult cochlear implant users. In: Ear and Hearing. 2005 ; Vol. 26, No. 4 SUPPL.
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