Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain

Vanaja Paul; E. Harihara Subramanian; Karthik Rajasekaran

doi:10.1016/S0197-0186(00)00081-4

Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain

Vanaja Paul, E. Harihara Subramanian, Karthik Rajasekaran

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The role of γ-aminobutyric acid (GABA) mechanism on the synthesis of nitric oxide (NO) has been investigated by measuring the activity of nitric oxide synthase (NOS) and the concentration of NO in rat brain 15 min after administration of anticonvulsant doses of diazepam (0.25 and 0.5 mg/kg) which is known to activate GABA A receptor for its anticonvulsant action. Diazepam enhanced both NOS activity and the concentration of NO in a dose-dependent manner. A reversal has been observed in animals treated with a convulsant dose of picrotoxin (5 mg/kg) which is known to produce convulsions by blocking GABA A receptor mechanism. These results suggest that a functional interaction occurs between GABA A receptor activity and NO synthesis in the brain. (C) 2001 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	209-211
Number of pages	3
Journal	Neurochemistry International
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/S0197-0186(00)00081-4
State	Published - 2001

Keywords

Diazepam
GABA A receptor
Nitric oxide
Picrotoxin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1016/S0197-0186(00)00081-4

Cite this

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title = "Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain",

abstract = "The role of γ-aminobutyric acid (GABA) mechanism on the synthesis of nitric oxide (NO) has been investigated by measuring the activity of nitric oxide synthase (NOS) and the concentration of NO in rat brain 15 min after administration of anticonvulsant doses of diazepam (0.25 and 0.5 mg/kg) which is known to activate GABA A receptor for its anticonvulsant action. Diazepam enhanced both NOS activity and the concentration of NO in a dose-dependent manner. A reversal has been observed in animals treated with a convulsant dose of picrotoxin (5 mg/kg) which is known to produce convulsions by blocking GABA A receptor mechanism. These results suggest that a functional interaction occurs between GABA A receptor activity and NO synthesis in the brain. (C) 2001 Elsevier Science Ltd.",

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AU - Rajasekaran, Karthik

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AB - The role of γ-aminobutyric acid (GABA) mechanism on the synthesis of nitric oxide (NO) has been investigated by measuring the activity of nitric oxide synthase (NOS) and the concentration of NO in rat brain 15 min after administration of anticonvulsant doses of diazepam (0.25 and 0.5 mg/kg) which is known to activate GABA A receptor for its anticonvulsant action. Diazepam enhanced both NOS activity and the concentration of NO in a dose-dependent manner. A reversal has been observed in animals treated with a convulsant dose of picrotoxin (5 mg/kg) which is known to produce convulsions by blocking GABA A receptor mechanism. These results suggest that a functional interaction occurs between GABA A receptor activity and NO synthesis in the brain. (C) 2001 Elsevier Science Ltd.

KW - Diazepam

KW - GABA A receptor

KW - Nitric oxide

KW - Picrotoxin

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Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain

Abstract

Keywords

ASJC Scopus subject areas

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