Pharmacological modulation of autophagy: Therapeutic potential and persisting obstacles

Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R. Green, Guido Kroemer

Research output: Contribution to journalReview article

254 Scopus citations

Abstract

Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.

Original languageEnglish (US)
Pages (from-to)487-511
Number of pages25
JournalNature Reviews Drug Discovery
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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