Pharmacotherapy and interventional treatments for secondary hyperparathyroidism: Current therapy and future challenges

Hirotaka Komaba, Kazuhiro Shiizaki, Masafumi Fukagawa

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Importance of the field: Chronic kidney disease is frequently complicated by secondary hyperparathyroidism, which causes bone disease and vascular calcification, leading to increased risk of morbidity and mortality. Areas covered in this review: This review covers treatment options for secondary hyperparathyroidism in patients receiving dialysis, particularly focusing on active vitamin D derivatives, calcimimetics and direct injection therapy into parathyroid glands. In addition, the potential of gene therapy is also described. What the reader will gain: The reader will gain a comprehensive review of the effectiveness and role of available therapies for patients with secondary hyperparathyroidism, as well as the results of observational studies that address the effect of these treatments on clinical outcomes. Take home message: Treatment with active vitamin D derivatives and calcimimetics allows adequate control of secondary hyperparathyroidism, which it is hoped will translate into improved clinical outcomes. These treatments appear to be effective even in patients with advanced disease, but patients who develop resistance to therapy should undergo parathyroid intervention, such as surgical parathyroidectomy and direct injection therapy. Gene therapy is not applicable to humans at present, but they will help clarify the molecular pathogenesis of secondary hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)1729-1742
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2010

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Keywords

  • calcimimetics
  • calcium-sensing receptor
  • direct injection therapy
  • gene therapy
  • secondary hyperparathyroidism
  • vitamin D
  • vitamin D receptor

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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