Pharmacotherapy of kidney stones

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Kidney stones are associated with various biochemical disturbances in urine. Various drugs and dietary changes have been recommended to halt stone recurrence. Objective: To determine whether a correction of urinary abnormalities by appropriate pharmacological agents and dietary modification may ameliorate stone disease. Methods: A review of the literature was conducted on the role of diet, metabolic disorders and drugs for stone prevention. Results/conclusion: Metabolic risk factors are hypercalciuria, hypocitraturia, hyperoxaluria, hyperuricosuria, and abnormally low urinary pH. Dietary-environmental risk factors include high urinary sodium and low urine volume. Rare or less commonly encountered risk factors are high urinary cystine, and alkaline urine from an infection with urea-splitting organisms. To ameliorate or correct the above disturbances, all patients should be offered dietary modification, including restricted intake of sodium, oxalate and animal proteins. Useful drugs include thiazide or indapamide to control hypercalciuria, potassium citrate to correct hypocitraturia and undue urinary acidity, and allopurinol for co-existing hyperuricemia or marked hyperuricosuria.

Original languageEnglish (US)
Pages (from-to)1509-1518
Number of pages10
JournalExpert Opinion on Pharmacotherapy
Volume9
Issue number9
DOIs
StatePublished - Jun 2008

Fingerprint

Kidney Calculi
Diet Therapy
Hypercalciuria
Urine
Drug Therapy
Potassium Citrate
Indapamide
Pharmaceutical Preparations
Hyperoxaluria
Thiazides
Oxalic Acid
Hyperuricemia
Allopurinol
Cystine
Urea
Sodium
Pharmacology
Diet
Recurrence
Infection

Keywords

  • Hypercalciuria
  • Hyperxaluria
  • Potassium citrate
  • Renal stone

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pharmacotherapy of kidney stones. / Pak, Charles Y C.

In: Expert Opinion on Pharmacotherapy, Vol. 9, No. 9, 06.2008, p. 1509-1518.

Research output: Contribution to journalArticle

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