Abstract
This phase 1, dose-finding study investigated ibrutinib and carfilzomib ± dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (≥2 lines of therapy including bortezomib and an immunomodulatory agent). Of 43 patients enrolled, 74% were refractory to bortezomib and 23% had high-risk cytogenetics. No dose-limiting toxicities were observed. The recommended phase 2 dose was ibrutinib 840 mg and carfilzomib 36 mg/m2 with dexamethasone. The most common ≥ grade 3 (>10%) treatment-emergent adverse events were hypertension, anemia, pneumonia, fatigue, diarrhea, and thrombocytopenia. Overall response rate was 67% (very good partial response, 21%; stringent complete response, 2%), with an additional 9% minimal response. Median progression-free survival was 7.2 months and was not inferior in refractory nor high-risk patients. Median overall survival was not reached. Ibrutinib plus carfilzomib demonstrated encouraging responses with a manageable safety profile in this advanced population.
Original language | English (US) |
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Pages (from-to) | 2588-2594 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 59 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2 2018 |
Keywords
- Bruton’s tyrosine kinase
- Ibrutinib
- carfilzomib
- hematologic neoplasms
- multiple myeloma
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research