Phase I study of docetaxel and topotecan in patients with advanced malignancies

Sarita Dubey, Paul Hutson, Dona Alberti, Rhoda Arzoomanian, Kim Binger, Jennifer Volkman, Chris Feierabend, George Wilding, Joan H. Schiller

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background. Docetaxel and topotecan are drugs with different mechanisms of action and significant activity against various tumour types. Topotecan may influence docetaxel metabolism by inhibiting the CYP3A4 enzyme. We designed a phase I study to evaluate the maximum tolerated dose of this combination and to assess the impact of pharmacokinetic interactions of the two drugs on toxicity. Methods. Docetaxel and topotecan were administered intravenously on day 1, and days 1-5 respectively, using a phase I dose escalation design. Plasma samples were analysed to determine docetaxel and topotecan concentration by HPLC with subsequent pharmacokinetic analysis using NONMEM. Results. Of the 17 patients enrolled in the trial, 11 had grade 3 and 4 neutropenia and 1 had grade 4 thrombocytopenia. Nonhaematological toxicities were less frequent. The maximum tolerated dose for docetaxel and topotecan were 60 mg/m2 on day 1 and 0.75 mg/m2 days 1-5., respectively. One patient had stable disease. Subjects with grade ≥3 haematologic toxicity had higher plasma docetaxel or topotecan area under the curve (AUC) (docetaxel 1.03±0.11 mg-hr/L versus 0.73±0.13 mg-hr/L; topotecan 65.8±14.6 mcg-hr/L, versus 41.6±13.9 mcg-hr/L). There was no additive effect of the AUC of the two drugs on the likelihood of grade ≥3 haematologic toxicity by multiple logistic regression. Conclusion. The dose-limiting toxicity seen with the combination of docetaxel and topotecan was myelosuppression. Future trials will require growth factor support if this combination is pursued.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalJournal of Oncology Pharmacy Practice
Volume11
Issue number4
DOIs
StatePublished - Dec 1 2005

Keywords

  • Docetaxel
  • Pharmacodynamics
  • Pharmacokinetics
  • Phase I
  • Topotecan

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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    Dubey, S., Hutson, P., Alberti, D., Arzoomanian, R., Binger, K., Volkman, J., Feierabend, C., Wilding, G., & Schiller, J. H. (2005). Phase I study of docetaxel and topotecan in patients with advanced malignancies. Journal of Oncology Pharmacy Practice, 11(4), 131-138. https://doi.org/10.1191/1078155205jp161oa